Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 26, 2023; 11(12): 2780-2787
Published online Apr 26, 2023. doi: 10.12998/wjcc.v11.i12.2780
Cardiac amyloidosis presenting as pulmonary arterial hypertension: A case report
Ming Gao, Wei-Hua Zhang, Zhi-Guo Zhang, Na Yang, Qian Tong, Li-Ping Chen
Ming Gao, Wei-Hua Zhang, Zhi-Guo Zhang, Na Yang, Qian Tong, Department of Cardiology, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Li-Ping Chen, Department of Echocardiography, Center of Cardiovascular Disease, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Gao M completed the clinical data collection and the manuscript draft; Chen LP and Yang N improved later revision of the article; Zhang WH and Tong Q participated in the treatment decisions; Zhang ZG, Zhang WH and Tong Q revised the manuscript critically to ensure the authenticity and practicability; All authors read and approved the final manuscript.
Informed consent statement: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee(s) and with the Helsinki Declaration (as revised in 2013). Written informed consent was obtained from the patient.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ming Gao, MD, Clinical Assistant Professor (Honorary), Doctor, Department of Cardiology, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. gmbeata@jlu.edu.cn
Received: January 13, 2023
Peer-review started: January 13, 2023
First decision: February 8, 2023
Revised: February 22, 2023
Accepted: March 30, 2023
Article in press: March 30, 2023
Published online: April 26, 2023
Core Tip

Core Tip: Symptomatic pulmonary hypertension is only rarely described and, when present, is typically associated with progressive disease, such as elevated filling pressures secondary to cardiac amyloid. In this case, the patient initially presented with pulmonary hypertension, she was found, 2 years later, to have amyloid light chain (AL) amyloidosis with cardiac involvement. We highlight the diagnostic difficulties presented by pulmonary hypertension in a patient with AL amyloidosis, and illustrate the complicated progression of the disease, as well as the poor efficacy of current palliative medicine.