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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 6, 2023; 11(1): 17-29
Published online Jan 6, 2023. doi: 10.12998/wjcc.v11.i1.17
Published online Jan 6, 2023. doi: 10.12998/wjcc.v11.i1.17
Endplate role in the degenerative disc disease: A brief review
Tomaz Velnar, Department of Neurosurgery, University Medical Centre Ljubljana, Ljubljana 1000, Slovenia
Tomaz Velnar, Lidija Gradisnik, Alma Mater Europaea Maribor, Maribor 2000, Slovenia
Lidija Gradisnik, Institute of Biomedical Sciences, University of Maribor, University of Maribor, Maribor 2000, Slovenia
Author contributions: Velnar T and Gradisnik L drafted the manuscript, participated in the design of the study and were involved with data collection, Velnar T participated in design and oversight of the study; all authors read and approved the final manuscript.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tomaz Velnar, MD, PhD, Doctor, Department of Neurosurgery, University Medical Centre Ljubljana, Zaloska 7, Ljubljana 1000, Slovenia. tvelnar@hotmail.com
Received: July 3, 2022
Peer-review started: July 3, 2022
First decision: August 22, 2022
Revised: October 19, 2022
Accepted: December 16, 2022
Article in press: December 16, 2022
Published online: January 6, 2023
Peer-review started: July 3, 2022
First decision: August 22, 2022
Revised: October 19, 2022
Accepted: December 16, 2022
Article in press: December 16, 2022
Published online: January 6, 2023
Core Tip
Core Tip: The degenerative disease of the intervertebral disc represents an important health problem worldwide. The endplate chondrocytes are one of the crucial cells involved in the first steps of the disc degeneration process. It is therefore not surprising that the endplate cells have been of significant interest from multiple perspectives, including growth, development, degeneration, remodelling, repair and treatment strategies. The importance of vertebral endplate in the intervertebral disc degeneration is discussed.