Observational Study
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World J Clin Cases. Mar 6, 2022; 10(7): 2147-2158
Published online Mar 6, 2022. doi: 10.12998/wjcc.v10.i7.2147
Association of types of diabetes and insulin dependency on birth outcomes
Pamela K Xaverius, Steven W Howard, Deborah Kiel, Jerry E Thurman, Ethan Wankum, Catherine Carter, Clairy Fang, Romi Carriere
Pamela K Xaverius, Deborah Kiel, Ethan Wankum, Department of Epidemiology and Biostatistics, Saint Louis University, St. Louis, MO 63104, United States
Steven W Howard, Department of Health Management and Policy, Saint Louis University, St. Louis, MO 63104, United States
Jerry E Thurman, Department of Endocrinology, Diabetes and Metabolism, SSM Health, St. Charles, MO 63303, United States
Catherine Carter, Division of Epidemiology, Institute for Health and Equity, Medical College of Wisconsin, Milwaukee, WI 53226, United States
Clairy Fang, Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, United States
Romi Carriere, Population Health Sciences Institute, Centre for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, England NE4 5PL, United Kingdom
Author contributions: Xaverius PK oversaw all aspects of this project including developing the research question, collecting and analyzing the data, and writing the overall manuscript; Xaverius PK and Kiel D designed the research study; Wankum E, Carter C, Fang C, and Carriere R analyzed the data; and Xaverius PK, Howard SW, and Thurman JE wrote the manuscript; All authors have read and approve the final manuscript.
Institutional review board statement: This study has been granted an exemption by the Institutional Review Board at Saint Louis University.
Conflict-of-interest statement: The authors have no financial or non-financial competing interests or conflicts of interests associated with this manuscript.
Data sharing statement: The data used in this manuscript were acquired from the Missouri Department of Health and Senior Services (MODHSS) and are not available for public access due to MODHSS guidelines. The contents of this document including data analysis, interpretation or conclusions are solely the responsibility of the authors and do not represent the official views of DHSS.
STROBE statement: The authors have read the STROBE Statement, and the manuscript was prepared and revised according to the STROBE Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Pamela K Xaverius, MA, PhD, Professor, Department of Epidemiology and Biostatistics, Saint Louis University, 3545 Lafayette Avenue, St. Louis, MO 63104, United States. pam.xaverius@slu.edu
Received: July 14, 2021
Peer-review started: July 14, 2021
First decision: August 8, 2021
Revised: September 21, 2021
Accepted: January 25, 2022
Article in press: January 25, 2022
Published online: March 6, 2022
Processing time: 230 Days and 11.7 Hours
Core Tip

Core Tip: This study investigated the differences in birth outcomes by timing of diabetes (pre-gestational and gestational) status and insulin use. The odds for preterm birth (PTB) and macrosomia were the most increased (187% and 201%, respectively) among women with insulin-dependent pre-pregnancy diabetes, followed by non-insulin dependent prepregnancy diabetes (77% and 112%, respectively) in comparison with women without diabetes. Women with insulin dependent gestational diabetes were also at an increased risk for PTB and macrosomia (73% and 95%, respectively). Clinical management of diabetes during pregnancy and healthy lifestyle behaviors before pregnancy can reduce the risk for diabetes and poor birth outcomes.