Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 26, 2022; 10(6): 1896-1902
Published online Feb 26, 2022. doi: 10.12998/wjcc.v10.i6.1896
Asymmetric limb weakness in Guillain-Barré syndrome: Three case reports
Ming Hu, Xiang Li, Hiu Yi Wong, Xun-Gang Feng, Yu-Zhong Wang, Guo-Rong Zhang
Ming Hu, Xun-Gang Feng, Guo-Rong Zhang, Department of Neurology, The Affiliated Hospital of Jining Medical University, Jining 272000, Shandong Province, China
Xiang Li, Department of Rehabilitation, The Affiliated Hospital of Jining Medical University, Jining 272000, Shandong Province, China
Hiu Yi Wong, Department of Physiology, Yong Loo Lin School of Medicine, Singapore 536205, Singapore
Yu-Zhong Wang, Department of Medical Research Center and Neurology, The Affiliated Hospital of Jining Medical University, Jining 272000, Shandong Province, China
Author contributions: Zhang GR and Hu M reviewed the literature and contributed to manuscript drafting; Li X and Feng XG played a major role in the acquisition of clinical data and the literature search; Wang YZ and Wong HY were responsible for the revision of the manuscript for important intellectual content; all authors issued final approval for the version to be submitted.
Supported by Teacher Research Support Foundation of Jining Medical University, No. JYFC2018FKJ140; Natural Science Foundation Youth Project of Shandong Province, No. ZR2020QH110.
Informed consent statement: Informed written consent was obtained from the three patients for publication of this report.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guo-Rong Zhang, Master of Medicine, Chief Doctor, Department of Neurology, The Affiliated Hospital of Jining Medical University, No. 89 Guhuai Road, Jining 272000, Shandong Province, China. rongrong.2.14@163.com
Received: July 20, 2021
Peer-review started: July 20, 2021
First decision: October 16, 2021
Revised: October 27, 2021
Accepted: January 19, 2022
Article in press: January 19, 2022
Published online: February 26, 2022
Processing time: 217 Days and 17.6 Hours
Core Tip

Core Tip: Atypical Guillain-Barré syndrome (GBS) with asymmetric limb weakness was rarely reported, which is easily confusing the diagnosis by clinicians. We herein present three patients diagnosed as GBS who suffered persistent asymmetric limb weakness from onset to recovery phase, two of which received immunotherapy in timely and had a good prognosis. Asymmetric blood-nerve barrier, ganglioside distribution or limb use may cause asymmetric GBS. To differentiate asymmetric GBS is important for an early treatment, which can lead to a good patient outcome and early recovery.