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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 6, 2022; 10(34): 12750-12760
Published online Dec 6, 2022. doi: 10.12998/wjcc.v10.i34.12750
Published online Dec 6, 2022. doi: 10.12998/wjcc.v10.i34.12750
Gingival enlargement induced by cyclosporine in Medullary aplasia: A case report
Giovanna Victory Rodríguez, Alondra del Carmen Ruiz Gutiérrez, Periodontics Program, Department of Integrated Dentistry Clinics, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico
Juan Ramón Gómez Sandoval, Research Institute of Dentistry, Department of Integrated Dentistry Clinics, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco , Mexico
Sarah Monserrat Lomelí Martínez, Department of Medical and Life Sciences, Centro Universitario de la Ciénega, Universidad de Guadalajara, Ocotlán 47810, Jalisco, Mexico
Author contributions: Victory Rodríguez G, Ruiz Gutiérrez ADC and Lomelí Martínez SM contributed to diagnosis, surgical treatment and manage of patient; Lomelí Martínez SM and Victory Rodríguez G contributed to acquisition and analysis of data; Ruiz Gutiérrez ADC and Gómez Sandoval JR drafted manuscript and critically revised manuscript; all authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sarah Monserrat Lomelí Martínez, Doctor, Academic Research, Associate Research Scientist, Department of Medical and Life Sciences, Centro Universitario de la Ciénega, Universidad de Guadalajara, Universidad No. 1115, Lindavista, Ocotlán 47810, Jalisco, Mexico. sarah.lomeli@academicos.udg.mx
Received: September 11, 2022
Peer-review started: September 11, 2022
First decision: September 26, 2022
Revised: October 8, 2022
Accepted: November 8, 2022
Article in press: November 8, 2022
Published online: December 6, 2022
Peer-review started: September 11, 2022
First decision: September 26, 2022
Revised: October 8, 2022
Accepted: November 8, 2022
Article in press: November 8, 2022
Published online: December 6, 2022
Core Tip
Core Tip: Medullary aplasia is a marrow failure characterized by a total or partial disappearance of hematopoietic precursors in bone marrow, resulting in pancytopenia which is usually accompanied by hemorrhagic syndrome. The treatment involves immunosuppressive therapy with cyclosporine. This drug suppresses the activity of immune cells that damage the bone marrow, although it may produce an inflammatory reaction, with increased fibrotic response in the extracellular matrix, and gingival enlargement (GE). We report a case of GE induced by cyclosporine in a patient with rare medullary aplasia, which was managed with a phased periodontal treatment plan.