Huang WP, Gao G, Qiu YK, Yang Q, Song LL, Chen Z, Gao JB, Kang L. Multimodality imaging and treatment of paranasal sinuses nuclear protein in testis carcinoma: A case report. World J Clin Cases 2022; 10(33): 12395-12403 [PMID: 36483827 DOI: 10.12998/wjcc.v10.i33.12395]
Corresponding Author of This Article
Lei Kang, MD, PhD, Doctor, Pharmacist, Professor, Department of Nuclear Medicine, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China. kanglei@bjmu.edu.cn
Research Domain of This Article
Radiology, Nuclear Medicine & Medical Imaging
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Nov 26, 2022; 10(33): 12395-12403 Published online Nov 26, 2022. doi: 10.12998/wjcc.v10.i33.12395
Multimodality imaging and treatment of paranasal sinuses nuclear protein in testis carcinoma: A case report
Wen-Peng Huang, Ge Gao, Yong-Kang Qiu, Qi Yang, Le-Le Song, Zhao Chen, Jian-Bo Gao, Lei Kang
Wen-Peng Huang, Yong-Kang Qiu, Qi Yang, Le-Le Song, Zhao Chen, Lei Kang, Department of Nuclear Medicine, Peking University First Hospital, Beijing 100034, China
Ge Gao, Department of Medical Imaging, Peking University First Hospital, Beijing 100034, China
Jian-Bo Gao, Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Author contributions: Huang WP, Gao G, Yang Q, Song LL Chen Z, and Qiu YK designed research; Huang WP, Gao G, Kang L and Gao JB performed research; Huang WP, Gao G and Kang L analyzed data; Huang WP, Gao G and Kang L wrote the paper.
Supported byThe Beijing Science Foundation for Distinguished Young Scholars, No. JQ21025.
Informed consent statement: Written informed consent for publication of clinical details and/or clinical images was obtained from the parents of the participant. A copy of the consent form is available for review by the Editor of the journal.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lei Kang, MD, PhD, Doctor, Pharmacist, Professor, Department of Nuclear Medicine, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China. kanglei@bjmu.edu.cn
Received: August 21, 2022 Peer-review started: August 21, 2022 First decision: September 26, 2022 Revised: September 28, 2022 Accepted: October 26, 2022 Article in press: October 26, 2022 Published online: November 26, 2022 Processing time: 93 Days and 21.5 Hours
Core Tip
Core Tip: This case demonstrates the aggressive and recurrence-prone biological behavior of nuclear protein in testis midline carcinoma (NMC). A variety of methods can be used to diagnose NMC, including immunohistochemistry, karyotyping, fluorescence in situ hybridization, reverse transcription-polymerase chain reaction, and next-generation sequencing. The patient achieved some degree of remission after radiation therapy and after initial treatment with anti-angiogenic drugs and sonodynamic therapy (SDT), but cannot achieve long-term stability and eventually developed distant metastases, with an overall survival of only 17 mo. This case is the first attempt to apply heat therapy and SDT in the treatment of NMC. Computed tomography (CT), Magnetic resonance imaging, and positron emission tomography/CT imaging are essential for the staging, management, treatment response assessment and monitoring of NMC.
