Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 26, 2022; 10(33): 12295-12304
Published online Nov 26, 2022. doi: 10.12998/wjcc.v10.i33.12295
Surgical and nutritional interventions for endometrial receptivity: A case report and review of literature
Dinorah Hernández-Melchor, Cecilia Palafox-Gómez, Ivan Madrazo, Ginna Ortiz, America Padilla-Viveros, Esther López-Bayghen
Dinorah Hernández-Melchor, America Padilla-Viveros, Science, Technology and Society Program, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, México City 07360, CDMX, México
Dinorah Hernández-Melchor, Clinical Research, Instituto Regenera SC, México City 05320, CDMX, México
Cecilia Palafox-Gómez, Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, México City 07360, CDMX, México
Ivan Madrazo, Ginna Ortiz, Investigación Clínica, Instituto de Infertilidad y Genética México SC, INGENES, México City 05320, CDMX, México
Esther López-Bayghen, Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City 07360, CDMX, México
Author contributions: Hernández-Melchor D, Palafox-Gómez C, and López-Bayghen E conceived the project. Ortiz G and Madrazo I performed the surgical procedures; Hernández-Melchor D and Palafox-Gómez C performed clinical data acquisition while Ortiz G and Madrazo I handled the case as the clinicians, collecting information regarding the parental history and in vitro fertilization data. López-Bayghen E, Hernández-Melchor D, and Palafox-Gómez C analyzed the data. López-Bayghen E and Hernández-Melchor D drafted the article. America Padilla critically revised the manuscript; all authors have approved the final version of the manuscript.
Supported by the National Council of Science and Technology of Mexico (CONACYT), No. 790971 (to Hernández-Melchor D), and No. 781208 to (to Palafox-Gómez C).
Informed consent statement: The patient and her partner provided written informed consent to participate in this study under the Declaration of Helsinki. Written informed consent was obtained from them for their anonymized information published in this article.
Conflict-of-interest statement: The authors have no relevant financial or non-financial interests to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Esther López-Bayghen, MSc, PhD, Academic Research, Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Avenida Instituto Politécnico Nacional 2508, San Pedro Zacatenco, México City 07360, CDMX, México. ebayghen@cinvestav.mx
Received: June 20, 2022
Peer-review started: June 20, 2022
First decision: August 4, 2022
Revised: August 16, 2022
Accepted: October 17, 2022
Article in press: October 17, 2022
Published online: November 26, 2022
Processing time: 155 Days and 12.2 Hours
Core Tip

Core Tip: Polycystic ovary syndrome (PCOS) is an endocrine disease that causes infertility due to ovulation disorders and impaired endometrial receptivity related to a pathological state of insulin resistance (IR). To date, endometrial dysfunctions are the rate-limiting factor for pregnancy in PCOS patients using in vitro fertilization. Here, an overweight PCOS patient with euploid embryos available for transfer achieved pregnancy only after a continuous nutritional intervention to correct IR and metabolic parameters and the enrichment of endometrial stem cell niche with mesenchymal stem cells from adipose tissue. In this case, endometrial thickness and receptivity were improved with a combination of nutritional and surgical interventions to achieve pregnancy.