Retrospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 6, 2022; 10(31): 11358-11370
Published online Nov 6, 2022. doi: 10.12998/wjcc.v10.i31.11358
Coxsackievirus A6 was the most common enterovirus serotype causing hand, foot, and mouth disease in Shiyan City, central China
Jing-Feng Li, Chuan-Jie Zhang, Ya-Wei Li, Chao Li, Shi-Chao Zhang, Sha-Sha Wang, Yong Jiang, Xin-Bing Luo, Xing-Juan Liao, Shou-Xin Wu, Ling Lin
Jing-Feng Li, Chao Li, Shi-Chao Zhang, Sha-Sha Wang, Yong Jiang, Xin-Bing Luo, Xing-Juan Liao, Department of Pediatrics, Taihe Hospital, Affiliated Hospital of Hubei University of Medicine, Shiyan 442000, Hubei Province, China
Chuan-Jie Zhang, Department of Children Health Care, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430061, Hubei Province, China
Ya-Wei Li, Department of Health Services, Taihe Hospital, Affiliated Hospital of Hubei University of Medicine, Shiyan 442000, Hubei Province, China
Shou-Xin Wu, Ling Lin, Department of Pharmaceuticals, Shanghai Biotecan Pharmaceuticals Co. Ltd., Shanghai 200000, China
Shou-Xin Wu, Ling Lin, Zhangjiang Center for Translational Medicine, Shanghai Zhangjiang Institute of Medical Innovation, Shanghai 442000, China
Author contributions: Li JF, Zhang CJ, and Li YW contributed equally to this study; Li JF, Zhang CJ, and Li YW designed and performed the research and co-wrote the paper; Li C, Wang SS, Zhang SC, Jiang Y, Luo XB, and Liao XJ collected the clinical specimens and the corresponding characteristics; Wu SX, and Lin L performed the serotypes identification of clinical samples; all authors have read and approved the final manuscript.
Supported by the Hubei Province Health and Family Planning A Scientific Research Project, No. WJ2017M220; the Wuhan Health Bureau Scientific Research Fund, No. WX19C11; the Joint Precision Medical Research Fund From Taihe Hospital, No. 2016JZ10; the Shiyan COVID-19 Pilot Emergency Scientific Research Project, No. 20Y19; and the Wuhan Children's Hospital Research Project, No. 2017FE007.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of the Taihe Hospital, Affiliated Hospital of Hubei University of Medicine (2017KS035). The study was carried out following the Code of Ethics of the World Medical Association (Declaration of Helsinki) for experiments involving humans.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All authors hereby declare that no conflict of interest exists.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing-Feng Li, MD, Chief Physician, Department of Pediatrics, Taihe Hospital, Affiliated Hospital of Hubei University of Medicine, No. 32 Renmin South Road, Shiyan 442000, Hubei Province, China. zihe1206@126.com
Received: July 19, 2022
Peer-review started: July 19, 2022
First decision: August 22, 2022
Revised: September 4, 2022
Accepted: September 20, 2022
Article in press: September 20, 2022
Published online: November 6, 2022
Processing time: 99 Days and 20.5 Hours
Core Tip

Core Tip: Hand, foot, and mouth disease (HFMD) has become China's most common infectious disease since 2008. Enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16) were the primary causal serotypes. However, the dominant serotypes shifted recently to other enteroviruses. Nevertheless, there has been no report on the prevalence of the pathogen spectrum in Hubei, central China, since 2017. Our findings revealed that CV-A6 was the most common HFMD pathogen in Shiyan City, displacing EV-A71 and CV-A16. Fever and myocardial damage were more common in HFMD caused by CV-A6.