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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 21, 2022; 10(3): 966-984
Published online Jan 21, 2022. doi: 10.12998/wjcc.v10.i3.966
Published online Jan 21, 2022. doi: 10.12998/wjcc.v10.i3.966
Patients with inflammatory bowel disease and post-inflammatory polyps have an increased risk of colorectal neoplasia: A meta-analysis
Jia-ling Shi, Ye-hong Lv, Jun Huang, Xue Huang, Ying Liu, Department of Geriatrics and Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Province, China
Author contributions: Shi JL and Huang X designed the research; Shi JL, Lv YH and Huang J performed the research; Huang J and Shi JL contributed analytic tools; Lv YH, Huang J, Huang X and Liu Y analyzed the data; Shi JL wrote the paper.
Supported by the National Natural Science Foundation of China , No. 81660093 .
Conflict-of-interest statement: The authors deny any conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xue Huang, PhD, Professor, Department of Geriatrics and Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Province, China. hb960305@163.com
Received: August 30, 2021
Peer-review started: August 30, 2021
First decision: October 27, 2021
Revised: November 5, 2021
Accepted: December 23, 2021
Article in press: December 23, 2021
Published online: January 21, 2022
Processing time: 137 Days and 21.6 Hours
Peer-review started: August 30, 2021
First decision: October 27, 2021
Revised: November 5, 2021
Accepted: December 23, 2021
Article in press: December 23, 2021
Published online: January 21, 2022
Processing time: 137 Days and 21.6 Hours
Core Tip
Core Tip: This study is the first systematic review and meta-analysis to separately evaluate the potential risk between post-inflammatory polyps (PIPs) and colorectal neoplasia, advanced colorectal neoplasia, and colorectal cancer. Interestingly, we found that although malignant transformation from PIPs is rare, inflammatory bowel disease (IBD) patients with PIPs still bear an increased incidence of various grades of colorectal neoplasia. As an early warning of the increasing risk of colorectal neoplasia, IBD patients with PIPs should undergo strengthened surveillance to detect early dysplastic changes to allow for appropriate management so that there are improvements in both quality of life and survival rates.