Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 21, 2022; 10(3): 1041-1049
Published online Jan 21, 2022. doi: 10.12998/wjcc.v10.i3.1041
Full recovery from chronic headache and hypopituitarism caused by lymphocytic hypophysitis: A case report
Mao-Guang Yang, Han-Qing Cai, Si-Si Wang, Lin Liu, Chun-Mei Wang
Mao-Guang Yang, Han-Qing Cai, Si-Si Wang, Lin Liu, Department of Endocrinology, The Second Hospital of Jilin University, Changchun 130000, Jilin Province, China
Chun-Mei Wang, Department of Radiology, The First Hospital of Jilin University, Changchun 130000, Jilin Province, China
Author contributions: Wang CM analyzed and interpreted the imaging findings and contributed to the manuscript drafting; Cai HQ contributed to the data curation and proofreading of the manuscript; Wang SS and Liu L were responsible for revising the manuscript for important intellectual content; Yang MG reviewed the literature; Wang CM and Yang MG contributed to the manuscript drafting; and all authors read and approve of the final manuscript.
Supported by the Nature Science Foundation of Jilin Province (No. 2018010113JC).
Informed consent statement: Informed consent was obtained from the patient.
Conflict-of-interest statement: The authors have no conflicts of interest to disclose.
CARE Checklist (2016) statement: The authors read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chun-Mei Wang, MA, Chief Doctor, Department of Radiology, The First Hospital of Jilin University, No. 1 Xinmin Avenue, Changchun 130000, Jilin Province, China. wangcm5413@jlu.edu.cn
Received: June 16, 2021
Peer-review started: June 16, 2021
First decision: June 25, 2021
Revised: July 5, 2021
Accepted: December 25, 2021
Article in press: December 25, 2021
Published online: January 21, 2022
Core Tip

Core Tip: Lymphocytic hypophysitis (LYH) is an important condition to consider in the differential diagnosis of patients with a pituitary mass, and headache is a frequent complaint of patients with LYH. We present a patient with LYH whose initial symptom was headache and who presented with repeatedly worsening and prolonged headaches three times even though the hypopituitarism was fully resolved after glucocorticoid treatment. This rare headache regression suggests that the cause of headaches in patients with LYH may not be exclusively due to the pituitary mass effect and that patients with chronic headaches should also be alerted to the possibility of LYH.