Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 6, 2022; 10(28): 10252-10259
Published online Oct 6, 2022. doi: 10.12998/wjcc.v10.i28.10252
Persistent diarrhea with petechial rash - unusual pattern of light chain amyloidosis deposition on skin and gastrointestinal biopsies: A case report
Shawna E Bilton, Nikhil Shah, Diana Dougherty, Sarah Simpson, Alex Holliday, Farhad Sahebjam, Douglas J Grider
Shawna E Bilton, Farhad Sahebjam, Douglas J Grider, Department of Basic Science Education, Virginia Tech Carilion School of Medicine, Roanoke, VA 24016, United States
Nikhil Shah, Department of Internal Medicine, Carilion Clinic, Roanoke, VA 24016, United States
Diana Dougherty, Farhad Sahebjam, Gastroenterology and Hepatology Section, Department of Internal Medicine, Carilion Clinic, Roanoke, VA 24016, United States
Sarah Simpson, Alex Holliday, Dermatology Section, Department of Internal Medicine, Carilion Clinic, Roanoke, VA 24016, United States
Douglas J Grider, Pathology, Dominion Pathology Associates, Roanoke, VA 24018, United States
Author contributions: Bilton SE and Shah N reviewed the literature and contributed to the manuscript drafting; Sahebjam F and Dougherty D performed gastroenterology consultation; Sahebjam F performed endoscopy with biopsy; Simpson S and Holliday A performed dermatology consultation and skin biopsy; Grider DJ performed pathology consultation, pathology interpretation, reviewed literature, and contributed to manuscript drafting; all authors reviewed the manuscript, provided edits, and issued final approval for the version to be submitted.
Informed consent statement: A written informed consent was obtained from the patient for publication of this case report.
Conflict-of-interest statement: The authors declare they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shawna E Bilton, BSc, Department of Basic Science Education, Virginia Tech Carilion School of Medicine, 2 Riverside Circle, Roanoke, VA 24016, United States. sbilton@vt.edu
Received: April 29, 2022
Peer-review started: April 29, 2022
First decision: May 11, 2022
Revised: May 31, 2022
Accepted: August 5, 2022
Article in press: August 5, 2022
Published online: October 6, 2022
Processing time: 150 Days and 17 Hours
Core Tip

Core Tip: Gastrointestinal involvement in systemic amyloid light (AL) amyloidosis is rare, and symptoms are usually subclinical. Diarrhea and hematochezia have rarely been the primary presenting symptom of AL amyloidosis. It is critically important to diagnose and treat amyloidosis early to prevent severe morbidity and mortality.