Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 16, 2022; 10(26): 9390-9397
Published online Sep 16, 2022. doi: 10.12998/wjcc.v10.i26.9390
Congenital lipoid adrenal hyperplasia with Graves' disease: A case report
Yan-Jun Wang, Cong Liu, Chuan Xing, Le Zhang, Wan-Feng Xu, Hai-Ying Wang, Fu-Tao Wang
Yan-Jun Wang, Cong Liu, Chuan Xing, Le Zhang, Wan-Feng Xu, Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Hai-Ying Wang, Department of Endocrinology, the Second Hospital of Chaoyang, Chaoyang 110000, Liaoning Province, China
Fu-Tao Wang, Department of Endocrinology, Changchun Central Hospital, Changchun 110000, Jilin Province, China
Author contributions: Wang YJ wrote and reviewed the manuscript; Liu C reviewed the manuscript; Xing C collected clinical data; Zhang L and Xu WF attended the patient; Wang HY and Wang FT made tables and figures; all authors have read and approved the final manuscript.
Informed consent statement: A written informed consent was obtained from the patient for publication of this case report.
Conflict-of-interest statement: The authors have nothing to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Yan-Jun Wang, PhD, Doctor, Department of Endocrinology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China.
Received: April 8, 2022
Peer-review started: April 8, 2022
First decision: May 31, 2022
Revised: June 3, 2022
Accepted: August 5, 2022
Article in press: August 5, 2022
Published online: September 16, 2022
Core Tip

Core Tip: Congenital lipoid adrenal hyperplasia (CAH) is the most severe form of CAH, which is caused by a mutation of the steroidogenic acute regulatory gene. This report describes the case of a 24-year-old woman with non-classic lipoid CAH combined with Graves' disease, which is the first of its kind in China. Additionally, the symptoms, presentation, and treatment of the comorbid condition have also been described. We believe that our study makes a significant contribution to the literature because it is an extremely rare case and, in this report, the clinical characteristics are comprehensively reported. Additionally, we provide guidance on how such a case could be effectively treated.