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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 16, 2022; 10(26): 9254-9263
Published online Sep 16, 2022. doi: 10.12998/wjcc.v10.i26.9254
Published online Sep 16, 2022. doi: 10.12998/wjcc.v10.i26.9254
Local inflammatory response to gastroesophageal reflux: Association of gene expression of inflammatory cytokines with esophageal multichannel intraluminal impedance-pH data
Sergey Morozov, Department of Gastroenterology, Hepatology and Nutrition, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow 115446, Russia
Tatyana Sentsova, Department of Hospital Pediatrics No. 2, Russian National Research Medical University named after N.I. Pirogov, Moscow 117997, Russia
Author contributions: Morozov S and Sentsova T designed this study; Morozov S collected and analyzed the data, performed statistical analysis, and drafted the manuscript; all authors critically revised the manuscript and approved its final version.
Supported by Ministry of Science and Higher Education , No. FGMF-2022-0005 and No. 0410-2020-0007 .
Institutional review board statement: The study was reviewed and approved by Ethic Committee of Federal Research Center of Nutrition and Biotechnology (No. 2, 06FEB2017).
Informed consent statement: All study participants provided written informed consent prior to study enrollment.
Conflict-of-interest statement: Dr. Morozov reports grants from Russian Science Foundation, personal fees from AstraZeneca, personal fees from AlfaSigma, non-financial support from Laborie, personal fees from DrFalk, personal fees from Takeda, from Federal Research Center of Nutrition and Biotechnology, outside the submitted work.
Data sharing statement: Technical appendix and dataset available from the corresponding author at reasonable request. Participants gave informed consent for anonymized data sharing.
STROBE statement: The authors have read the STROBE statement – checklist of items and the manuscript was prepared and revised according to STROBE statement – checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sergey Morozov, MD, PhD, Doctor, Senior Researcher, Department of Gastroenterology, Hepatology and Nutrition, Federal Research Center of Nutrition, Biotechnology and Food Safety, Kashirskoye shosse, 21, Moscow 115446, Russia. morosoffsv@mail.ru
Received: March 16, 2022
Peer-review started: March 16, 2022
First decision: April 10, 2022
Revised: April 21, 2022
Accepted: August 12, 2022
Article in press: August 12, 2022
Published online: September 16, 2022
Peer-review started: March 16, 2022
First decision: April 10, 2022
Revised: April 21, 2022
Accepted: August 12, 2022
Article in press: August 12, 2022
Published online: September 16, 2022
Core Tip
Core Tip: Local expression of cytokines may be involved in pathophysiology of different forms of gastroesophageal reflux disease. We found a different profile of local expression of cytokines in subgroups of patients with erosive esophagitis and non-erosive forms of gastroesophageal reflux disease. For the first time we have revealed a correlation between gene expression of interleukin-18, tumor necrosis factor alpha, GATA binding protein 3, toll-like receptor 4, differentiation cluster 68 and mean esophageal pH and an association of acid exposure with expression of interleukin-1β, interleukin-18, tumor necrosis factor alpha, toll-like receptor 4, differentiation cluster 68 and β-2 microglobulin.