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World J Clin Cases. Sep 16, 2022; 10(26): 9241-9253
Published online Sep 16, 2022. doi: 10.12998/wjcc.v10.i26.9241
Early diagnostic value of liver stiffness measurement in hepatic sinusoidal obstruction syndrome induced by hematopoietic stem cell transplantation
You-Wen Tan, Yi-Chun Shi
You-Wen Tan, Yi-Chun Shi, Department of Hepatology, The Third Hospital of Zhenjiang Affiliated Jiangsu University, Zhenjiang 212003, Jiangsu Province, China
Author contributions: Tan YW and Shi YC wrote and revised the manuscript; and approved the final version to be published.
Conflict-of-interest statement: All authors have no conflicts of interest related to this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: You-Wen Tan, MD, Chief Doctor, Professor, Department of Hepatology, The Third Hospital of Zhenjiang Affiliated Jiangsu University, No. 300 Daijiamen, Runzhou Distinct, Zhenjiang 212003, Jiangsu Province, China.
Received: June 2, 2022
Peer-review started: June 2, 2022
First decision: June 18, 2022
Revised: June 27, 2022
Accepted: August 6, 2022
Article in press: August 6, 2022
Published online: September 16, 2022
Core Tip

Core Tip: Clinical diagnosis of hematopoietic stem cell transplantation (HSCT)-sinusoidal obstruction syndrome (SOS) is based on the revised Seattle or Baltimore standards. Eight studies have shown the value of liver stiffness measurement (LSM) in the early diagnosis of HSCT-SOS. Four studies investigated the specificity and sensitivity of LSM for the early diagnosis of HSCT-SOS. Therefore, LSM can distinguish SOS from other post-HSCT complications, enabling a clear differential diagnosis. The early diagnosis of SOS is beneficial in preventing severe HSCT complications.