Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 6, 2022; 10(25): 9004-9011
Published online Sep 6, 2022. doi: 10.12998/wjcc.v10.i25.9004
Coexistent Kaposi sarcoma and post-transplant lymphoproliferative disorder in the same lymph nodes after pediatric liver transplantation: A case report
Shu-Hong Zhang, Guang-Yong Chen, Zhi-Jun Zhu, Lin Wei, Ying Liu, Jing-Yi Liu
Shu-Hong Zhang, Guang-Yong Chen, Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
Zhi-Jun Zhu, Lin Wei, Ying Liu, Jing-Yi Liu, Liver Transplantation Center, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
Zhi-Jun Zhu, Lin Wei, Ying Liu, Jing-Yi Liu, Clinical Center for Pediatric Liver Transplantation, Capital Medical University, Beijing 100050, China
Ying Liu, Jing-Yi Liu, Department of Critical Liver Diseases, Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
Author contributions: Zhang SH reviewed the literature, drafted the manuscript, and revised the manuscript for important intellectual content; Cheng GY collected the pathological data; Zhu ZJ, Wei L, Liu Y, and Liu JY provided and analyzed the clinical data; all authors have read and approve the final manuscript.
Supported by the Digestive Medical Coordinated Development Center of Beijing Hospitals Authority, No. XXX0102.
Informed consent statement: Informed written consent was obtained from the patient’s parents for publication of this report and any accompanying images.
Conflict-of-interest statement: All authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shu-Hong Zhang, MD, Doctor, Department of Pathology, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong-an Road, Xicheng District, Beijing 100050, China. 13552880233@163.com
Received: March 14, 2022
Peer-review started: March 14, 2022
First decision: April 8, 2022
Revised: April 24, 2022
Accepted: July 29, 2022
Article in press: July 29, 2022
Published online: September 6, 2022
Processing time: 165 Days and 5.1 Hours
Core Tip

Core Tip: We report a rare case of coexistent Kaposi sarcoma and post-transplant lymphoproliferative disorder in the same lymph nodes after a pediatric liver transplant. The definitive diagnosis was based on histopathological examination of the lymph nodes. The patient recovered after discontinuation of the immunosuppressants and application of anti-CD20 monoclonal antibody (rituximab) therapy. In conclusion, the concurrent occurrence of these two disorders may be associated with immunodeficiency as well as Epstein-Barr virus and human herpesvirus-8 coinfection.