Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 16, 2022; 10(23): 8242-8248
Published online Aug 16, 2022. doi: 10.12998/wjcc.v10.i23.8242
Epstein–Barr-virus-associated hepatitis with aplastic anemia: A case report
Wan-Jun Zhang, Li-Qiang Wu, Jun Wang, Sheng-Yun Lin, Bo Wang
Wan-Jun Zhang, Li-Qiang Wu, Jun Wang, Sheng-Yun Lin, Bo Wang, Department of Hematology, The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang Province, China
Author contributions: Zhang WJ collected, analyzed the data and wrote the manuscript; Wu LQ, Wang J, Lin SY and Wang B made the treatment plan of the patient and participated in the whole process of patient treatment; and all authors have read and approve the final manuscript.
Informed consent statement: Before treatment, patients and their families have signed informed consent for treatment.
Conflict-of-interest statement: There is no conflict of interest among all authors.
CARE Checklist (2016) statement: This manuscript was checked according to the checklist (2016) statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bo Wang, MM, Attending Doctor, Department of Hematology, The First Affiliated Hospital, Zhejiang Chinese Medical University, No. 54 Youdian Road, Hangzhou 310006, China. w_bo1223@163.com
Received: December 28, 2021
Peer-review started: December 28, 2021
First decision: April 8, 2022
Revised: April 19, 2022
Accepted: June 27, 2022
Article in press: June 27, 2022
Published online: August 16, 2022
Processing time: 215 Days and 19.9 Hours
Core Tip

Core tip: We found an unexpected association between Epstein–Barr virus (EBV) and hepatitis-associated aplastic anemia (HAAA). Reports on EBV-associated HAAA are sparse. HAAA is a type of severe AA, and the treatment strategy pursued was in accordance with the 2016 British guidelines for AA. The patient achieved a complete response after immunosuppressive therapy. This current study highlights the importance of early diagnosis and timely therapy for EBV-associated HAAA.