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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 16, 2022; 10(23): 8205-8211
Published online Aug 16, 2022. doi: 10.12998/wjcc.v10.i23.8205
Published online Aug 16, 2022. doi: 10.12998/wjcc.v10.i23.8205
Role of serum β2-microglobulin, glycosylated hemoglobin, and vascular endothelial growth factor levels in diabetic nephropathy
Bing Yang, Xiao-Hong Zhao, Guo-Bin Ma, Department of Endocrinology and Metabolism, 3201 Hospital, Xi’an Jiaotong University Health Science Center, Hanzhong 723099, Shaanxi Province, China
Author contributions: Yang B contributed to conceptualization, data analysis, and writing; Zhao XH contributed to data analysis and writing; Ma GB revised the manuscript; and all authors have read and approved the manuscript.
Institutional review board statement: The study was reviewed and approved by the 3201 Hospital Institutional Review Board.
Informed consent statement: Informed consent was obtained from all study participants or their legal guardians prior to enrolment.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: Data supporting the findings of this study can be found within the article.
STROBE statement: The manuscript was prepared and revised according to the STROBE statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bing Yang, MM, Associate Chief Physician, Department of Endocrinology and Metabolism, 3201 Hospital, Xi’an Jiaotong University Health Science Center, No. 783 Tianhan Avenue, Hanzhong 723099, Shaanxi Province, China.
Received: May 6, 2022
Peer-review started: May 6, 2022
First decision: June 7, 2022
Revised: June 18, 2022
Accepted: July 6, 2022
Article in press: July 6, 2022
Published online: August 16, 2022
Processing time: 86 Days and 22.7 Hours
Peer-review started: May 6, 2022
First decision: June 7, 2022
Revised: June 18, 2022
Accepted: July 6, 2022
Article in press: July 6, 2022
Published online: August 16, 2022
Processing time: 86 Days and 22.7 Hours
Core Tip
Core Tip: This study investigated the relationship between diabetic nephropathy (DN) and the expression of serum β2-microglobulin (β2-MG), glycosylated hemoglobin (HbA1c), and vascular endothelial growth factor (VEGF). In total, 107 patients with type 2 diabetes mellitus complicated by nephropathy were included in this study. Additionally, 107 healthy individuals were included in the control group. The expression levels of these factors, from high to low, were evaluated in the different groups by pairwise comparison. Serum β2-MG, HbA1c, and VEGF were all closely correlated with DN progression based on all indicators.