Retrospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 16, 2022; 10(23): 8141-8151
Published online Aug 16, 2022. doi: 10.12998/wjcc.v10.i23.8141
Diagnostic value of elevated serum carbohydrate antigen 125 level in sarcoidosis
Qian Zhang, Xiao-Yan Jing, Xiao-Yu Yang, Zuo-Jun Xu
Qian Zhang, Xiao-Yan Jing, Xiao-Yu Yang, Zuo-Jun Xu, Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Author contributions: Zhang Q participated in study design and drafted the manuscript; Jing XY and Yang XY participated in data collection and performed the statistical analysis; Xu ZJ revised the manuscript; and All authors read and approved the final manuscript.
Supported by Municipal Natural Science Foundation of Beijing of China, No. 7212076; and National Natural Science Foundation of China (General Program), No. 82070067.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Peking Union Medical College Hospital.
Informed consent statement: Informed consent was obtained from all individual participants included in the study.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zuo-Jun Xu, MD, PhD, Chief Doctor, Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifu Yuan, Dongcheng District, Beijing 100730, China. xuzjdoc@163.com
Received: March 11, 2022
Peer-review started: March 11, 2022
First decision: May 11, 2022
Revised: May 21, 2022
Accepted: July 11, 2022
Article in press: July 11, 2022
Published online: August 16, 2022
Processing time: 142 Days and 21.9 Hours
Core Tip

Core Tip: This study revealed the overexpression of carbohydrate antigen 125 in sarcoidosis patients, and a close association between the expression level with the percentage of predicted of forced vital capacity measured in pulmonary function test and radiological Scadding’s classification of sarcoidosis. Carbohydrate antigen 125 may be a noninvasive diagnostic biomarker for sarcoidosis patients and may serve as a biomarker in the clinical prediction of sarcoidosis.