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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 26, 2022; 10(21): 7415-7421
Published online Jul 26, 2022. doi: 10.12998/wjcc.v10.i21.7415
Published online Jul 26, 2022. doi: 10.12998/wjcc.v10.i21.7415
Corticosteroid-induced bradycardia in multiple sclerosis and maturity-onset diabetes of the young due to hepatocyte nuclear factor 4-alpha mutation: A case report
Sung-Yeon Sohn, Shin Yeop Kim, In Soo Joo, Department of Neurology, Ajou University School of Medicine, Ajou University Medical Center, Suwon 16499, South Korea
Author contributions: Sohn S-Y conceptualized, investigated and wrote the manuscript; Kim SY investigated and reviewed the manuscript; Joo IS supervised, reviewed and edited the manuscript.
Informed consent statement: Written informed consent was obtained from the patient.
Conflict-of-interest statement: All authors report no relevant conflict of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: In Soo Joo, MD, Professor, Department of Neurology, Ajou University School of Medicine, Ajou University Medical Center, No.164 World Cup Road, Yongtong District, Suwon 16499, South Korea. isjoo@ajou.ac.kr
Received: September 24, 2021
Peer-review started: September 24, 2021
First decision: March 3, 2022
Revised: April 8, 2022
Accepted: June 4, 2022
Article in press: June 4, 2022
Published online: July 26, 2022
Processing time: 289 Days and 22.2 Hours
Peer-review started: September 24, 2021
First decision: March 3, 2022
Revised: April 8, 2022
Accepted: June 4, 2022
Article in press: June 4, 2022
Published online: July 26, 2022
Processing time: 289 Days and 22.2 Hours
Core Tip
Core Tip: Corticosteroid administration may cause cardiac arrhythmias including severe bradycardia. The accompanying T-wave abnormalities may provide clues regarding the pathophysiology of corticosteroid-induced bradycardia. This case report highlights the need for clinical vigilance during high-dose corticosteroid administration, particularly in potentially vulnerable patients harboring genetic variants.