Meta-Analysis
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 26, 2022; 10(21): 7386-7396
Published online Jul 26, 2022. doi: 10.12998/wjcc.v10.i21.7386
Impact of cancer on mortality rates in patients with sepsis: A meta-analysis and meta-regression of current studies
Mei-Jiao Xiang, Guo-Liang Chen
Mei-Jiao Xiang, Department of Comprehensive Intensive Care Unit, Jinhua People’s Hospital, Jinhua 321000, Zhejiang Province, China
Guo-Liang Chen, Department of Hepatobiliary Pancreatic Gastrointestinal Surgery, Jinhua People's Hospital, Jinhua 321000, Zhejiang Province, China
Author contributions: Xiang MJ conceived and designed the study; Xiang MJ and Chen GL were involved in literature search and data collection; Chen GL analyzed the data; Xiang MJ and Chen GL wrote the paper; Xiang MJ edited the manuscript; all authors read and approved the final manuscript.
Conflict-of-interest statement: The authors deny any conflict of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guo-Liang Chen, MD, Doctor, Department of Hepatobiliary Pancreatic Gastrointestinal Surgery, Jinhua People's Hospital, No. 267 Danxi East Road, Jinhua 321000, Zhejiang Province, China. glchenjh@163.com
Received: January 4, 2022
Peer-review started: January 4, 2022
First decision: February 21, 2022
Revised: March 4, 2022
Accepted: May 22, 2022
Article in press: May 22, 2022
Published online: July 26, 2022
Processing time: 188 Days and 1.2 Hours
Core Tip

Core Tip: Therapeutic advances in the past two decades have resulted in several advances in the management of cancer as well as sepsis patients. However, it is unclear if active cancer results in worse clinical outcomes in sepsis patients. We pooled the data from nine recent studies to demonstrate that cancer results in a 2.7 times increased risk of mortality in sepsis patients. The outcomes are similar for both solid tumors and hematological cancers. There is a need for further research taking into account several confounding variables to present better evidence.