Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 16, 2022; 10(20): 7116-7123
Published online Jul 16, 2022. doi: 10.12998/wjcc.v10.i20.7116
Malignant histiocytosis associated with mediastinal germ cell tumor: A case report
Pei-Yi Yang, Xiao-Li Ma, Wen Zhao, Li-Bing Fu, Rui Zhang, Qi Zeng, Hong Qin, Tong Yu, Yan Su
Pei-Yi Yang, Xiao-Li Ma, Wen Zhao, Yan Su, Department of Medical Oncology, Pediatric Oncology Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China
Li-Bing Fu, Department of Pathology, Beijing Children’s Hospital, Capital Medical University, National Center of Children’s Health, Beijing 100045, China
Rui Zhang, Hematology Center, Beijing Children’s Hospital, Capital Medical University, National Center of Children’s Health, Beijing 100045, China
Qi Zeng, Department of Thoracic Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China
Hong Qin, Department of Surgical Oncology, Capital Medical University, National Center for Children’s Health, Beijing 100045, China
Tong Yu, Department of Image Center, Beijing Children’s Hospital, Capital Medical University, National Center of Children’s Health, Beijing 100045, China
Author contributions: Yang PY, Ma XL and Zhao W were the patient’s oncology physicians, reviewed the literature, and contributed to manuscript drafting; Fu LB analyzed the pathological findings; Zhang R contributed to the patient’s treatment for malignant histiocytosis; Zeng Q and Qin H were the patient’s surgeons; Yu T interpreted the imaging findings; Su Y was responsible for the revision of the manuscript for important intellectual content; all authors issued final approval for the version to be submitted.
Informed consent statement: Informed consent was obtained from the patient’s parents.
Conflict-of-interest statement: The authors have no conflicts of interest relevant to this article to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan Su, MM, Chief Physician, Department of Medical Oncology, Pediatric Oncology Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, No. 56 South Lishi Road, Beijing 100045, China. suyanbch@sina.com
Received: December 31, 2021
Peer-review started: December 31, 2021
First decision: February 14, 2022
Revised: February 28, 2022
Accepted: May 28, 2022
Article in press: May 28, 2022
Published online: July 16, 2022
Processing time: 185 Days and 9.8 Hours
Core Tip

Core Tip: Association between mediastinal germ cell tumor (MGCT) and hematologic malignancies has been recognized. We report a case in which the malignant histiocytosis were associated with MGCT. The patient was diagnosed as MGCT first, and one year after stopping chemotherapy, imaging showed metastases in mediastinum, retroperitoneal lymph node and adjacent tissues. Then he was diagnosed as malignant histiocytosis according to pathological examination, and accepted chemotherapy. The patient has been followed up for 10 mo with no sign of progression or relapse. Physicians who take care of patients with MGCT should be aware of the possibilities of associated hematologic malignancies.