Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 16, 2022; 10(20): 6999-7005
Published online Jul 16, 2022. doi: 10.12998/wjcc.v10.i20.6999
Clinical features and genetic variations of severe neonatal hyperbilirubinemia: Five case reports
Fen Lin, Jian-Xin Xu, Yong-Hao Wu, Yu-Bin Ma, Li-Ye Yang
Fen Lin, Jian-Xin Xu, Yong-Hao Wu, Precision Medical Center, Chaozhou Central Hospital Affiliated to Southern Medical University, Chaozhou 521021, Guangdong Province, China
Fen Lin, Department of Biochemistry, Shantou University Medical College, Shantou 515000, Guangdong Province, China
Yu-Bin Ma, Department of Pediatrics, Chaozhou Central Hospital Affiliated to Southern Medical University, Chaozhou 521000, Guangdong Province, China
Li-Ye Yang, Precision Medical Lab Center, People’s Hospital of Yangjiang Affiliated to Guangdong Medical University, Yangjiang 529500, Guangdong Province, China
Author contributions: Yang LY conceived the study and revised the manuscript; Lin F performed all experiments and wrote the manuscript; Xu JX collected the blood samples and biochemical analyses of the patients; Wu YH collected the clinical data, and Ma YB performed the treatments; All authors read and approved the final manuscript.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Ye Yang, MD, Professor, Precision Medical Lab Center, People’s Hospital of Yangjiang Affiliated to Guangdong Medical University, No. 42 Dongshan Road, Jiangcheng District, Yangjiang 529500, Guangdong Province, China. yangleeyee@sina.com
Received: November 1, 2021
Peer-review started: November 1, 2021
First decision: March 23, 2022
Revised: April 6, 2022
Accepted: May 22, 2022
Article in press: May 22, 2022
Published online: July 16, 2022
Processing time: 245 Days and 17.1 Hours
Core Tip

Core Tip: This study has emphasized that for severe hyperbilirubinemia neonates, apart from the predominant glucose-6-phosphate dehydrogenase deficiency and ABO hemolysis, other underlying genetic factors such as thalassemia or red blood cell membrane disorders should be considered, and genetic detection may be taken into consideration for early diagnosis of severe hyperbilirubinemia in neonates.