Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 16, 2022; 10(20): 6944-6953
Published online Jul 16, 2022. doi: 10.12998/wjcc.v10.i20.6944
Clinical expression and mitochondrial deoxyribonucleic acid study in twins with 14484 Leber’s hereditary optic neuropathy: A case report
Wanicha Leetiratanai Chuenkongkaew, Buakhwan Chinkulkitnivat, Patcharee Lertrit, Niphon Chirapapaisan, Supannee Kaewsutthi, Bhoom Suktitipat, Chalermchai Mitrpant
Wanicha Leetiratanai Chuenkongkaew, Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok10170, Thailand
Buakhwan Chinkulkitnivat, Niphon Chirapapaisan, Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
Patcharee Lertrit, Supannee Kaewsutthi, Bhoom Suktitipat, Chalermchai Mitrpant, Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
Bhoom Suktitipat, Integrative Computational BioScience Center, Mahidol University, Nakhon Pathom 73170, Thailand
Author contributions: Chuenkongkaew WL designed the report, analyzed the data and made critical revisions; Chinkulkitnivat B contributed to manuscript drafting; Lertrit P and Suktitipat B analyzed and interpreted the data; Chirapapaisan N analyzed and interpreted the imaging findings; Kaewsutthi S and Mitrpant C collected the patients’ data; all authors issued final approval for the version to be submitted.
Supported by the Faculty of Medicine Siriraj Hospital, Mahidol University, No. (IO) R015731040.
Informed consent statement: Informed written consent was obtained from the patients for the publication of this report and any accompanying images.
Conflict-of-interest statement: All authors have no conflict of interest related to the manuscript.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wanicha Leetiratanai Chuenkongkaew, MD, Professor, Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, 85/82 Moo 4 Soi Chimplee 28, Talinchan 10170, Bangkok, Thailand. wim.wanicha@gmail.com
Received: September 20, 2021
Peer-review started: September 20, 2021
First decision: December 27, 2021
Revised: January 7, 2022
Accepted: May 13, 2022
Article in press: May 13, 2022
Published online: July 16, 2022
Processing time: 287 Days and 3.5 Hours
Core Tip

Core Tip: This is the first report of a pair of monozygotic twins homoplasmic for 14484T>C mutation discordant for Leber’s hereditary optic neuropathy during an 11-year follow-up. This interval between the discordant pair of twins is the longest reported to date.