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World J Clin Cases. Jul 6, 2022; 10(19): 6341-6348
Published online Jul 6, 2022. doi: 10.12998/wjcc.v10.i19.6341
Review of clinical characteristics, immune responses and regulatory mechanisms of hepatitis E-associated liver failure
Chong Chen, Shu-Ye Zhang, Liang Chen
Chong Chen, Department of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China
Shu-Ye Zhang, Liang Chen, Department of Hepatology, Shanghai Public Health Clinical Center, Shanghai 201508, China
Author contributions: Chen C, Zhang SY and Chen L contributed equally to all aspects of the work.
Supported by Shanghai Shenkang Hospital Development Center, No. SHDC12020109; Shanghai Association for Science and Technology, No. 21S11905600; and Plan of the Research Project Funded by Shanghai Public Health Clinical Centre, No. KY-GW-2022-22.
Conflict-of-interest statement: All the authors declare no conflict of interest related to the manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Liang Chen, MD, Chief Physician, Department of Hepatology, Shanghai Public Health Clinical Center, No. 2901 Caolang Road, Jin-Shan District, Shanghai 201508, China. chenliang@shphc.org.cn
Received: January 8, 2022
Peer-review started: January 8, 2022
First decision: March 9, 2022
Revised: March 17, 2022
Accepted: May 5, 2022
Article in press: May 5, 2022
Published online: July 6, 2022
Processing time: 166 Days and 21.9 Hours
Core Tip

Core Tip: Hepatitis E virus (HEV) is the most common cause of acute liver failure (LF) and a common factor causing acute injury in acute-on-chronic LF (ACLF). The whole immune environment in the body during HEV-related LF is complicated. This review highlights recent progress in elucidating the clinical manifestations of HEV-associated acute LF and ACLF and discusses the corresponding systemic immune changes and possible regulatory mechanisms.