Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 26, 2022; 10(18): 6277-6282
Published online Jun 26, 2022. doi: 10.12998/wjcc.v10.i18.6277
De novo brain arteriovenous malformation formation and development: A case report
Huan Huang, Xue Wang, An-Na Guo, Wei Li, Ren-Hua Duan, Jun-Hao Fang, Bo Yin, Dan-Dong Li
Huan Huang, Xue Wang, An-Na Guo, Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Wei Li, Ren-Hua Duan, Jun-Hao Fang, Bo Yin, Dan-Dong Li, Department of Neurosurgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Author contributions: Li DD was in charge of case review and preparation of the manuscript; Huang H, Wang X, Guo AN, and Li W collected clinical opinions regarding this case and drafted the manuscript; Duan RH, Fang JH, and Yin B participated in the coordinating the manuscript; Huang H and Li DD revised the manuscript; All authors read and approved the final manuscript.
Supported by the Science and Technology Program of Wenzhou, China, No. Y20190145 to Huan Huang; and the Beijing New Health Industry Development Foundation, No. XM2020-02-002 to Bo Yin.
Informed consent statement: Written informed consent was obtained from the patient’s parents.
Conflict-of-interest statement: The authors declare there are no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dan-Dong Li, MD, Neurosurgeon, Department of Neurosurgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 108 Xueyuan West Road, Wenzhou 325000, Zhejiang Province, China. andonglmn@163.com
Received: January 13, 2022
Peer-review started: January 13, 2022
First decision: March 23, 2022
Revised: April 1, 2022
Accepted: April 27, 2022
Article in press: April 27, 2022
Published online: June 26, 2022
Processing time: 154 Days and 12.1 Hours
Core Tip

Core Tip: Brain arteriovenous malformation (AVM) is one of the main causes of spontaneous cerebral hemorrhage in children. At present, the mechanism of the occurrence and development of AVM is not clear, and there have been very few case reports that have documented the progression of a de novo brain AVM. In this report, we present the case of a child with a de novo brain AVM. Brain AVM was first detected in this child at the age of 7 years and 4 mo and was significantly advanced and hemorrhaging at the age of 12 years and 8 mo. Genetic analysis of this patient revealed a mutation in the NOTCH2 (p.Asp473Val) gene.