Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 26, 2022; 10(18): 6156-6162
Published online Jun 26, 2022. doi: 10.12998/wjcc.v10.i18.6156
Liver transplantation for late-onset ornithine transcarbamylase deficiency: A case report
Xiao-Hui Fu, Yu-Hui Hu, Jian-Xiang Liao, Li Chen, Zhan-Qi Hu, Jia-Lun Wen, Shu-Li Chen
Xiao-Hui Fu, Yu-Hui Hu, Shu-Li Chen, Department of Inherited Metabolic Disorders, The Affiliated Hospital of China Medical University and Shenzhen Children’s Hospital, Shenzhen 518038, Guangdong Province, China
Jian-Xiang Liao, Li Chen, Zhan-Qi Hu, Jia-Lun Wen, Department of Neurology, The Affiliated Hospital of China Medical University and Shenzhen Children’s Hospital, Shenzhen 518038, Guangdong Province, China
Author contributions: Hu YH, Liao JX, Chen L, Hu ZQ and Wen JL were responsible for the treatment and management of the patient; Fu XH and Chen SL collected the patient’s clinical data and wrote the paper; all authors were involved in writing the manuscript and read and approved the final manuscript.
Supported by the Sanming Project of Medicine in Shenzhen, No. SZSM201812005.
Informed consent statement: Informed written consent was obtained from the patient for the publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shu-Li Chen, PhD, Chief Doctor, Department of Inherited Metabolic Disorders, The Affiliated Hospital of China Medical University and Shenzhen Children’s Hospital, No. 7019 Yitian Road, Futian District, Shenzhen 518038, Guangdong Province, China. 13008803656@163.com
Received: October 28, 2021
Peer-review started: October 28, 2021
First decision: December 27, 2021
Revised: January 10, 2022
Accepted: April 22, 2022
Article in press: April 22, 2022
Published online: June 26, 2022
Processing time: 231 Days and 14.7 Hours
Core Tip

Core Tip: There are differing views on the timing of liver transplantation (LT) for ornithine transcarbamylase deficiency (OTCD) and whether it makes sense to perform LT in a patient with severe neurological impairment. We report a case of late-onset OTCD with severe neurological impairment, whose nervous system function recovered after LT. In late-onset OTCD patients with severe neurological impairment, LT can be considered.