Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 26, 2022; 10(18): 6110-6118
Published online Jun 26, 2022. doi: 10.12998/wjcc.v10.i18.6110
Pembrolizumab-induced Stevens-Johnson syndrome in advanced squamous cell carcinoma of the lung: A case report and review of literature
Jing-Yi Wu, Kai Kang, Jing Yi, Bin Yang
Jing-Yi Wu, Jing Yi, Bin Yang, Department of Thoracic Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Techonology, Wuhan 430000, Hubei Province, China
Kai Kang, Department of Thoracic Oncology Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430070, Hubei Province, China
Author contributions: Wu JY and Kang K designed the study and performed the experiments; Yi J, Yang B, and Wu JY performed the experiments, analyzed the data, and wrote the manuscript; Wu JY and Kang K contributed to this article equally.
Informed consent statement: Consent was obtained from the patient for publication of this report.
Conflict-of-interest statement: The authors declare that they have no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bin Yang, MS, Academic Fellow, Academic Research, Additional Professor, Department of Thoracic Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Techonology, No. 116 Zhuo Daoquan South Road, Wuhan 430000, Hubei Province, China. dlhdr2011@163.com
Received: October 10, 2021
Peer-review started: October 10, 2021
First decision: December 10, 2021
Revised: December 24, 2021
Accepted: April 30, 2022
Article in press: April 30, 2022
Published online: June 26, 2022
Processing time: 249 Days and 16.9 Hours
Core Tip

Core Tip: Stevens-Johnson syndrome (SJS) is a rare but extremely severe cutaneous adverse drug reaction with high mortality. The case involved a 68-year-old female who was diagnosed with advanced squamous cell carcinoma of the lung. SJS syndrome appeared after one cycle of immunotherapy. After the optimal supportive treatment, skin toxicity disappeared.