Meta-Analysis
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 16, 2022; 10(17): 5690-5701
Published online Jun 16, 2022. doi: 10.12998/wjcc.v10.i17.5690
Systematic review of Yougui pills combined with levothyroxine sodium in the treatment of hypothyroidism
Xiao-Pei Liu, Ya-Nan Zhou, Cong-E Tan
Xiao-Pei Liu, Ya-Nan Zhou, Cong-E Tan, School of Basic Medicine, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi Province, China
Author contributions: Tan CE and Liu XP conceptualized and designed the protocol, drafted the initial manuscript and reviewed the manuscript; Liu XP and Zhou YN defined the concepts and search items and performed the data extraction process as well as methodological appraisal of the studies; Zhou YN and Tan CE planned the data extraction and statistical analysis; Liu XP and Tan CE provided critical insights; All authors have approved and contributed to the final written manuscript.
Supported by the National Natural Science Foundation of China, No. 81973754; Shaanxi University of Traditional Chinese Medicine Innovation Team Project, No. 2019-QN06.
Conflict-of-interest statement: The authors deny any conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Cong-E Tan, PhD, School of Basic Medicine, Shaanxi University of Chinese Medicine, Xixian Avenue, Xixian New District, Xianyang 712046, Shaanxi Province, China. tanzime@163.com
Received: October 27, 2021
Peer-review started: October 27, 2021
First decision: February 14, 2022
Revised: March 10, 2022
Accepted: April 21, 2022
Article in press: April 21, 2022
Published online: June 16, 2022
Processing time: 224 Days and 21.3 Hours
Core Tip

Core Tip: The combined treatment of Yougui pills and levothyroxine sodium can effectively reduce or eliminate the adverse reactions caused by the use of hormones, increase the secretion of hormones in serum and thus significantly improve the clinical symptoms of hypothyroidism. We recommended the use of levothyroxine sodium in combination with Yougui pills in patients with hypothyroidism.