Retrospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 16, 2022; 10(17): 5634-5645
Published online Jun 16, 2022. doi: 10.12998/wjcc.v10.i17.5634
Assessment of incidental focal colorectal uptake by analysis of fluorine-18 fluorodeoxyglucose positron emission tomography parameters
Haejun Lee, Kyung-Hoon Hwang, Kwang An Kwon
Haejun Lee, Kyung-Hoon Hwang, Department of Nuclear Medicine, Gachon University College of Medicine, Gil Medical Center, Incheon 21565, South Korea
Kwang An Kwon, Department of Gastroenterology, Gachon University College of Medicine, Gil Medical Center, Incheon 21565, South Korea
Author contributions: Lee H and Hwang KH contributed to this work; Lee H and Hwang KH designed the research study; Lee H, Kwon KA and Hwang KH performed the research; Lee H contributed analytic tools; Lee H, Kwon KA and Hwang KH analyzed the data and wrote the manuscript; and all authors have read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board at our institution. The requirement for informed consent was waived.
Conflict-of-interest statement: The authors have no potential conflicts of interest to disclose.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at [forrest88@hanmail.net]. Informed consent for data sharing was waived because of the retrospective nature of the study and this retrospective study was approved by the Institutional Review Board of our hospital (IRB No. GAIRB2020-297).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kyung-Hoon Hwang, MD, PhD, Professor, Department of Nuclear Medicine, Gachon University College of Medicine, Gil Medical Center, 21, Namdong-daero 774 beon-gil, Namdong-gu, Incheon 21565, South Korea. forrest88@hanmail.net
Received: December 27, 2021
Peer-review started: December 27, 2021
First decision: January 25, 2022
Revised: February 11, 2022
Accepted: April 9, 2022
Article in press: April 29, 2022
Published online: June 16, 2022
Processing time: 164 Days and 3.1 Hours
Core Tip

Core Tip: Although intestinal fluorine-18 fluorodeoxyglucose (F-18 FDG) uptake is not a rare finding on F-18 FDG positron emission tomography/computed tomography, focal colorectal uptake may harbor malignant lesions. Therefore, it is important to differentiate between malignant/premalignant and benign lesions. The present study compared PET parameters such as standardized uptake value (SUV), metabolic tumor volume, mean SUV of metabolic tumor volume, and total lesion glycolysis among the malignant, premalignant, and benign incidental focal hypermetabolism to evaluate the implications of unexpectedly observed focal colorectal FDG uptake.