Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 6, 2022; 10(13): 4190-4195
Published online May 6, 2022. doi: 10.12998/wjcc.v10.i13.4190
Paraneoplastic neurological syndrome with positive anti-Hu and anti-Yo antibodies: A case report
Zi-Chao Li, Hong-Bin Cai, Zhen-Zhen Fan, Xiao-Bin Zhai, Zhao-Ming Ge
Zi-Chao Li, Hong-Bin Cai, Zhen-Zhen Fan, Xiao-Bin Zhai, Zhao-Ming Ge, Department of Neurology, Lanzhou University Second Hospital, Lanzhou 730000, Gansu Province, China
Author contributions: Li ZC were the patient’s neurologist, reviewed the literature and contributed to manuscript drafting; Cai HB analyzed and interpreted the imaging findings; Fan ZZ and Zhai XB were responsible for the revision of the manuscript for important intellectual content; and all authors issued final approval for the version to be submitted; the manuscript was supported by Ge ZM.
Supported by Natural Science Foundation of Gansu Province, No. 20JR10RA719.
Informed consent statement: Written informed consent for the publication of the clinical details and the radiological images was obtained from the patient.
Conflict-of-interest statement: There are no conflicts of interest related to this report.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhao-Ming Ge, MD, Chief Doctor, Department of Neurology, Lanzhou University Second Hospital, No. 82 Cuiyingmen, Chengguan District, Lanzhou 730000, Gansu Province, China. gezhaoming123456@163.com
Received: September 8, 2021
Peer-review started: September 8, 2021
First decision: October 27, 2021
Revised: November 5, 2021
Accepted: March 14, 2022
Article in press: March 14, 2022
Published online: May 6, 2022
Processing time: 234 Days and 2.2 Hours
Core Tip

Core Tip: Neurological paraneoplastic syndrome is a common manifestation in patients with tumors, and in some cases, it appears earlier than the tumor. We report a rare case in which two different paraneoplastic antibodies were present. While most previous studies have reported this syndrome due to one tumor, this patient presented with two different tumors and two paraneoplastic antibodies at the same time, causing neurological symptoms such as ataxia, limb numbness, and weakness. This case highlights the specificity of paraneoplastic antibodies to their corresponding tumors, avoiding a missed diagnosis when multiple antibodies are present and providing a reference for future clinical diagnosis.