Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 26, 2022; 10(12): 3916-3922
Published online Apr 26, 2022. doi: 10.12998/wjcc.v10.i12.3916
Anti-glomerular basement membrane disease with IgA nephropathy: A case report
Chuan Guo, Ming Ye, Shen Li, Ting-Ting Zhu, Xiang-Rong Rao
Chuan Guo, Ming Ye, Shen Li, Ting-Ting Zhu, Xiang-Rong Rao, Department of Nephrology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
Author contributions: Guo C analyzed this case and wrote the manuscript; Ye M and Li S guided the discussion part; Zhu TT provided follow-up data of the patient; Rao XR provided treatment and directed the writing of the manuscript; all authors have read and approve the final manuscript.
Informed consent statement: The patient signed a written informed consent form.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiang-Rong Rao, PhD, Professor, Department of Nephrology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No. 5 North line Pavillion, Xicheng District, Beijing 100053, China. raoyisheng@163.com
Received: September 16, 2021
Peer-review started: September 16, 2021
First decision: October 25, 2021
Revised: November 18, 2021
Accepted: March 6, 2022
Article in press: March 6, 2022
Published online: April 26, 2022
Processing time: 216 Days and 15.7 Hours
Core Tip

Core Tip: This case reported a rare disease with both anti-glomerular basement membrane (GBM) disease and Immunoglobulin A (IgA) nephropathy. Its clinical manifestations and prognosis are better than those of simple anti-GBM disease. The patient's condition was improved and the renal function was relatively stable with the treatment of corticosteroids and cyclophosphamide. About 70% of the glomeruli contained crescents, and multiple crescents formed in this patient's renal biopsy pathology. New detection methods to identify whether the crescents in this case were derived from anti-GBM disease or IgA nephropathy are worthy of further exploration.