Pi YN, Xiao Y, Wang ZF, Lin GL, Qiu HZ, Fang XC. Anorectal dysfunction in patients with mid-low rectal cancer after surgery: A pilot study with three-dimensional high-resolution manometry. World J Clin Cases 2022; 10(12): 3754-3763 [PMID: 35647175 DOI: 10.12998/wjcc.v10.i12.3754]
Corresponding Author of This Article
Xiu-Cai Fang, MD, Chief Physician, Full Professor, Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. fangxiucai2@aliyun.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Yan-Na Pi, Zhi-Feng Wang, Xiu-Cai Fang, Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Yi Xiao, Guo-Le Lin, Hui-Zhong Qiu, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Author contributions: Fang XC and Xiao Y were the guarantors and designed the study, enrolled and followed the patients, and critically revised the manuscript; Pi YN collected and analyzed the data and wrote the manuscript; Wang ZF participated in manometry and data interpretation; Lin GL and Qiu HZ enrolled and followed the patients; all authors reviewed the final version of this manuscript and agreed to its submission.
Supported bythe National High-tech R & D Program (“863” Program) of China, No. 2010AA023007.
Institutional review board statement: The study was reviewed and approved by the Science and Research Office of Peking Union Medical College Hospital (Beijing).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: Data can be acquired from the corresponding author at fangxiucai2@aliyun.com.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiu-Cai Fang, MD, Chief Physician, Full Professor, Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. fangxiucai2@aliyun.com
Received: November 4, 2021 Peer-review started: November 4, 2021 First decision: December 27, 2021 Revised: January 8, 2022 Accepted: March 6, 2022 Article in press: March 6, 2022 Published online: April 26, 2022 Processing time: 168 Days and 5.6 Hours
Core Tip
Core Tip: Rectal cancer is one of the most common malignant tumors in the world. Most patients with mid-low rectal cancer treated by anterior resections suffer anterior resection syndrome (ARS), which seriously impairs the quality of life and mental status. Therefore, the factors impacting anorectal function and its underlying mechanism need to be adequately investigated. Three-dimensional high-resolution anorectal manometry (3D HR-ARM), a more detailed instrument than traditional one, has rarely been used in these patients. In this study, we compared the perioperative anorectal functions of mid-low rectal cancer patients by 3D HR-ARM. Based on these data, focal pressure defects of the anal canal and spastic peristaltic contractions from the new rectum to anus postoperatively might be the major pathophysiological mechanisms of low ARS.
