Retrospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 7, 2022; 10(1): 79-90
Published online Jan 7, 2022. doi: 10.12998/wjcc.v10.i1.79
Distribution of transient receptor potential vanilloid-1 channels in gastrointestinal tract of patients with morbid obesity
Unal Atas, Nuray Erin, Gokhan Tazegul, Gulsum Ozlem Elpek, Bülent Yıldırım
Unal Atas, Gokhan Tazegul, Department of Internal Medicine, Akdeniz University Medical School, Antalya 07070, Turkey
Nuray Erin, Department of Pharmacology, Akdeniz University Medical School, Antalya 07070, Turkey
Gulsum Ozlem Elpek, Department of Pathology, Akdeniz University Medical School, Antalya 07070, Turkey
Bülent Yıldırım, Department of Gastroenterology, Akdeniz University Medical School, Antalya 07070, Turkey
Author contributions: Atas U, Erin N, and Yildirim B designed the study and collected materials; Elpek GO evaluated the histopathological findings; Tazegul G provided analytical tools; all authors assessed the results; Atas U and Tazegul G wrote the manuscript; Erin N, Yildirim B and Elpek GO critically revised the draft; and all the authors checked the final version of the manuscript.
Institutional review board statement: The study was reviewed and approved by the Scientific Research Projects Coordination Unit of Akdeniz University, No. 2333.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There is no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gulsum Ozlem Elpek, MD, Professor, Research Assistant Professor, Department of Pathology, Akdeniz University Medical School, Dumlupınar Bulvarı, Antalya 07070, Turkey. elpek@akdeniz.edu.tr
Received: April 21, 2021
Peer-review started: April 21, 2021
First decision: June 13, 2021
Revised: June 25, 2021
Accepted: November 23, 2021
Article in press: November 23, 2021
Published online: January 7, 2022
Core Tip

Core Tip: Capsaicin-associated pathways may provide an alternative approach for obesity treatment. Our results suggest that transient receptor potential vanilloid (TRPV1) activation can provide anti-obesity and gastroprotective activity. TRPV1 distribution in the gastric and duodenal mucosal cells of morbidly obese people is similar to that in patients with normal weight. Hence, drugs targeting TRPV1 may be an effective approach in these patients. Further studies are needed in this area.