Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 7, 2022; 10(1): 242-248
Published online Jan 7, 2022. doi: 10.12998/wjcc.v10.i1.242
Intraoperative thromboelastography-guided transfusion in a patient with factor XI deficiency: A case report
Wen-Juan Guo, Wei-Yun Chen, Xue-Rong Yu, Le Shen, Yu-Guang Huang
Wen-Juan Guo, Wei-Yun Chen, Xue-Rong Yu, Yu-Guang Huang, Department of Anesthesiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China
Le Shen, Department of Anesthesiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China
Author contributions: Guo WJ contributed to the clinical conduct of the case, to data collection, and to the writing of the manuscript; Chen WY and Yu XR contributed to the intraoperative TEG assessment; Shen L and Huang YG contributed to the analysis and interpretation of the collected data and to the revision of the manuscript.
Supported by Education Reform Project Foundation for the Central Universities of Peking Union Medical College, No. 2020zlgc0105; Training Programme Foundation for Excellent Talent in Dongcheng District of Beijing, No. 2019DCT-M-08; and Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences, No. 2019XK320018.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Le Shen, MD, PhD, Professor, Department of Anesthesiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Beijing 100730, China. pumchshenle@163.com
Received: December 27, 2020
Peer-review started: December 27, 2020
First decision: July 8, 2021
Revised: July 12, 2021
Accepted: November 25, 2021
Article in press: November 25, 2021
Published online: January 7, 2022
Processing time: 367 Days and 9 Hours
Core Tip

Core Tip: Factor XI (FXI) deficiency is a rare bleeding disorder of unpredictable severity that correlates poorly with FXI coagulation activity and that poses great challenges for perioperative hemostatic management. Thromboelastography (TEG) is a method for testing blood coagulation using a viscoelastic hemostatic assay of whole blood to assess overall coagulation status; it is readily available and provides real-time monitoring. This case report highlights the importance of using TEG in the intraoperative period to individualize transfusion needs for patients with rare inherited coagulopathy and to minimize transfusion-related risks.