Randomized Controlled Trial
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 7, 2022; 10(1): 227-235
Published online Jan 7, 2022. doi: 10.12998/wjcc.v10.i1.227
Zinc carnosine-based modified bismuth quadruple therapy vs standard triple therapy for Helicobacter pylori eradication: A randomized controlled study
Nour Ibrahim, Hassan El Said, Ali Choukair
Nour Ibrahim, Faculty of Medical Sciences, Lebanese University, Beirut 0000, Lebanon
Hassan El Said, Department of Biological and Chemical Sciences, School of Arts and Sciences, Lebanese International University, Beirut 0000, Lebanon
Ali Choukair, Department of Gastroenterology, Clemenceau Medical Center, Dubai 00000, United Arab Emirates
Author contributions: Choukair A designed the study, collected the data and wrote the first draft of the manuscript; Ibrahim N analyzed the data and contributed to the manuscript writing; all authors critically revised the manuscript and read and approved the final version of the manuscript.
Supported by Synergy Group
Institutional review board statement: This study was reviewed and approved by the Clinical Research Ethics Committee of NMC specialty hospital.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nour Ibrahim, MD, Research Fellow, Faculty of Medical Sciences, Lebanese University, Old Saida Road Street, Hadath Area, Beirut 0000, Lebanon.nouribrahim5@hotmail.com
Received: June 25, 2021
Peer-review started: June 25, 2021
First decision: July 27, 2021
Revised: August 7, 2021
Accepted: November 28, 2021
Article in press: November 28, 2021
Published online: January 7, 2022
Core Tip

Core Tip: High eradication failure rate of Helicobacter pylori (H. pylori) infection has been reported due to increasing antibiotic resistance. This necessitates the need for better alternative regimens. The present study revealed higher H. pylori eradication rate with the use of zinc carnosine-based modified bismuth quadruple therapy for 10 d than with 14 d of standard triple therapy.