Retrospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 7, 2022; 10(1): 155-165
Published online Jan 7, 2022. doi: 10.12998/wjcc.v10.i1.155
Characterization of focal hypermetabolic thyroid incidentaloma: An analysis with F-18 fluorodeoxyglucose positron emission tomography/computed tomography parameters
Haejun Lee, Yoo Seung Chung, Joon-Hyop Lee, Ki-Young Lee, Kyung-Hoon Hwang
Haejun Lee, Kyung-Hoon Hwang, Department of Nuclear Medicine, Gachon University College of Medicine, Gil Medical Center, Incheon 21565, South Korea
Yoo Seung Chung, Joon-Hyop Lee, Department of Endocrine Surgery, Gachon University College of Medicine, Gil Medical Center, Incheon 21565, South Korea
Ki-Young Lee, Department of Endocrinology and Metabolism, Gachon University College of Medicine, Gil Medical Center, Incheon 21565, South Korea
Author contributions: Lee H and Hwang KH contributed to this work; Lee H and Hwang KH designed the research study; Lee H, Chung YS, Lee JH, Lee KY and Hwang KH performed the research; Lee H contributed analytic tools; Lee H, Chung YS, Lee JH, Lee KY and Hwang KH analyzed the data and wrote the manuscript; and all authors have read and approved the final manuscript.
Institutional review board statement: This retrospective study was approved by the institutional review board of our hospital (IRB no. GAIRB2020-297), and the requirement to obtain informed consent was waived. The study was conducted in accordance with the 1964 Declaration of Helsinki and later amendments.
Informed consent statement: The requirement to obtain informed consent was waived.
Conflict-of-interest statement: The authors have no potential conflicts of interest to disclose.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at [forrest88@hanmail.net].
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kyung-Hoon Hwang, MD, Professor, Department of Nuclear Medicine, Gachon University College of Medicine, Gil Medical Center, Namdong-daero 774 beon-gil, Namdong-gu, Incheon 21565, South Korea. forrest88@hanmail.net
Received: August 19, 2021
Peer-review started: August 19, 2021
First decision: September 29, 2021
Revised: October 9, 2021
Accepted: November 22, 2021
Article in press: November 22, 2021
Published online: January 7, 2022
Processing time: 133 Days and 4.4 Hours
Core Tip

Core Tip: An unexpected focal thyroid incidentaloma (TI) is detected on various medical imaging studies. The lesion may harbor a risk of malignancy and the differentiation between malignant and benign disease is important. Standardized uptake value (SUV) is often measured for metabolism on F-18 fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT). Parameters of FDG PET-CT, including SUV, have been studied for many years in the fields of nuclear medicine and oncology. We conducted the present study to distinguish malignant TI from benign disease with an analysis of FDG PET-CT parameters.