Cao JJ, Yun CH, Xiao J, Liu Y, Wei W, Zhang W. Analysis of the incidence and influencing factors of hyponatremia before 131I treatment of differentiated thyroid carcinoma. World J Clin Cases 2021; 9(36): 11173-11182 [PMID: 35071548 DOI: 10.12998/wjcc.v9.i36.11173]
Corresponding Author of This Article
Wei Zhang, MD, Professor, Department of Nuclear Medicine, The Second Hospital, Cheeloo College of Medicine, Shandong University, No. 247 Road, Tianqiao District, Jinan 250033, Shandong Province, China. sdeyzhangwei@126.com
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Retrospective Cohort Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jing-Jia Cao, Can-Hua Yun, Juan Xiao, Yong Liu, Wei Wei, Wei Zhang, Department of Nuclear Medicine, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, Shandong Province, China
Author contributions: Cao JJ, Yun CH, Xiao J, Liu Y and Wei W contributed acquisition of data; Cao JJ, Yun CH and Xiao J contributed analysis of data, drafting the article; Zhang W conceived and designed the study; all authors have read and approved the final manuscript.
Institutional review board statement: The study was approved by the Institutional Review Board of the Second Hospital, Cheeloo College of Medicine, Shandong University (KYLL-2018[LW]013). All procedures complied with the Declaration of Helsinki for research involving human subjects.
Informed consent statement: Written informed consent was obtained from each patient.
Conflict-of-interest statement: All authors have no conflict of interest related to the manuscript.
Data sharing statement: The original anonymous dataset is available on request from the corresponding author.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei Zhang, MD, Professor, Department of Nuclear Medicine, The Second Hospital, Cheeloo College of Medicine, Shandong University, No. 247 Road, Tianqiao District, Jinan 250033, Shandong Province, China. sdeyzhangwei@126.com
Received: May 11, 2021 Peer-review started: May 11, 2021 First decision: July 8, 2021 Revised: August 3, 2021 Accepted: November 15, 2021 Article in press: November 15, 2021 Published online: December 26, 2021 Processing time: 226 Days and 11 Hours
ARTICLE HIGHLIGHTS
Research background
Hyponatremia in chronic hypothyroidism is commonly seen in clinical practice. However, the association between hyponatremia and acute hypothyroidism is unclear. Acute hypothyroidism is usually seen in patients who undergo preparation for radioactive iodine therapy.
Research motivation
The incidence and influencing factors of hyponatremia before 131I treatment in China are still unclear. This article will offer our center's experience of the management of thyroid cancer patients prior to 131I therapy.
Research objectives
To improve patient management during the preparation period for 131I treatment. The cause of hyponatremia was not further investigated in this study. Thus, further studies with larger sample sizes, including prospective studies, are needed in the future to verify these results.
Research methods
An observational study design was used in this clinical study. Patients with and without hyponatremia were studied by univariate and multivariate analysis. The sample size in this study was larger than those reported in previous publications.
Research results
The incidence of hyponatremia induced by 131I treatment preparation was not high (2.5%). Twenty-three (2.5%) patients were diagnosed with hyponatremia before 131I treatment, including 21 cases (91.3%) of mild hyponatremia and 2 cases (8.7%) of moderate hyponatremia.
Research conclusions
This study indicates that preparation for radioactive iodine therapy is not a risk factor for the development of hyponatremia in thyroid cancer patients.
Research perspectives
Measurement of sodium post-radioactive iodine therapy should be considered in patients.
