Suo Lang DJ, Ci Ren YZ, Bian Ba ZX. Minimally invasive surgery vs laparotomy in patients with colon cancer residing in high-altitude areas. World J Clin Cases 2021; 9(35): 10919-10926 [PMID: 35047602 DOI: 10.12998/wjcc.v9.i35.10919]
Corresponding Author of This Article
Duo-Ji Suo Lang, MHSc, Attending Doctor, General Surgery, Peoples Hospital of Tibet Autonomous Region, No. 18 North Linkuo Road, Chengguan District, Lasa 850000, Tibet Autonomous Region, China. suolang469563645@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Dec 16, 2021; 9(35): 10919-10926 Published online Dec 16, 2021. doi: 10.12998/wjcc.v9.i35.10919
Minimally invasive surgery vs laparotomy in patients with colon cancer residing in high-altitude areas
Duo-Ji Suo Lang, Yang-Zhen Ci Ren, Zha-Xi Bian Ba
Duo-Ji Suo Lang, Zha-Xi Bian Ba, Department of General Surgery, People’s Hospital of Tibet Autonomous Region, Lasa 850000, Tibet Autonomous Region, China
Yang-Zhen Ci Ren, Department of Internal Medicine, The Tibet Autonomous Region Centers for Disease Control and Prevention, Lasa 850000, Tibet Autonomous Region, China
Author contributions: Suo Lang DJ and Ci Ren YZ designed this retrospective study; Suo Lang DJ wrote this paper; Suo Lang DJ, Ci Ren YZ and Bian Ba ZX were responsible for sorting the data.
Institutional review board statement: The study was reviewed and approved by the People’s Hospital of Tibet Autonomous Region Institutional Review Board (Approval No. ME-TBHP-21-KJ-025).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: Nothing to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Duo-Ji Suo Lang, MHSc, Attending Doctor, General Surgery, Peoples Hospital of Tibet Autonomous Region, No. 18 North Linkuo Road, Chengguan District, Lasa 850000, Tibet Autonomous Region, China. suolang469563645@163.com
Received: August 12, 2021 Peer-review started: August 12, 2021 First decision: September 2, 2021 Revised: September 7, 2021 Accepted: October 20, 2021 Article in press: October 20, 2021 Published online: December 16, 2021 Processing time: 119 Days and 23 Hours
ARTICLE HIGHLIGHTS
Research background
Hypoxic environment at high altitudes increases the risk of colon cancer.
Research motivation
This study investigated the advantages of laparoscopic surgery in the treatment of colon cancer in the plateau area.
Research objectives
The authors aimed to examine the effect of minimally invasive surgery vs laparotomy in patients with colon cancer residing in high-altitude areas.
Research methods
Ninety-two patients with colon cancer were included. The surgical conditions in the two groups, including duration, intraoperative blood loss, recovery time of gastrointestinal function and number of lymph nodes dissected, were measured. The inflammatory factor levels were measured before and after surgery in the groups. The immune function index before and after surgery was determined.
Research results
The operative duration was longer in the minimally invasive group than in the laparotomy group, whereas intraoperative blood loss and recovery time of gastrointestinal function were less in the minimally invasive group than in the laparotomy group. After surgery, these levels were significantly higher in the minimally invasive group than in the laparotomy group. The counts were lower in both groups, with CD3+, CD4+, and CD4+/CD8+ counts being significantly higher in the minimally invasive group than in the laparotomy group.
Research conclusions
The results suggest that the laparoscopic surgery for colon cancer in patients residing in high-altitude areas can reduce surgical trauma, alleviate inflammatory response and immune dysfunction caused by invasive surgery and thereby shorten the recovery time of body functions and reduce the risk of complications in these patients.
Research perspectives
The advantages of laparoscopic surgery for patients with other diseases can be explored in the future.
