Published online Dec 6, 2021. doi: 10.12998/wjcc.v9.i34.10626
Peer-review started: May 8, 2021
First decision: June 5, 2021
Revised: June 6, 2021
Accepted: August 17, 2021
Article in press: August 17, 2021
Published online: December 6, 2021
Tracheal intubation is the most commonly used airway management method in general anesthesia. However, this approach has been associated with some problems, such as postoperative airway complications, which are common phenomena and adverse reactions in patients who underwent elective general anesthesia. To reduce the occurrence of postoperative airway-related complications, many interventions have been proposed. Among these, intracuff alkalinized lidocaine can be used as local anesthesia, to reduce complications during extubation, and to avoid the side effects of lidocaine on the circulation and central nervous system during general application.
Intracuff lidocaine can be used as local anesthesia, to reduce complications during extubation, and to avoid the side effects of lidocaine on the circulation and central nervous system during general application. Nevertheless, lidocaine is not easy to diffuse in the cuff, and adding sodium bicarbonate can greatly enhance the diffusion ability of lidocaine, to achieve better action on the tracheal mucosa.
Perform a systematic review and meta-analysis to summarize the efficacy of intracuff alkalinized lidocaine in the prevention of postoperative airway-related complications.
A comprehensive literature search of Pubmed (until May 2020), Embase (until May 2020), Cochrane (until May 2020), and Web of Science (until May 2020) was performed. Heterogeneity was assessed using the Cochrane Q test and I2 statistic. A fixed-effect model was used if heterogeneity was considered low. If I2 statistic ≥ 50% and P < 0.05, a random-effects model was applied to the data.
Twelve randomized trials (1175 patients) met the inclusion criteria. The meta-analysis showed that intracuff alkalinized lidocaine was associated with less cough compared to that produced by placebo. Similarly, intracuff alkalinized lidocaine was more effective than the control in reducing postoperative sore throat at 24 h and post
Intracuff alkalinized lidocaine decreased postoperative airway complications, in
The use of intracuff alkalinized lidocaine after tracheal intubation is a simple, eco