Lyu YE, Xu XF, Dai S, Feng M, Shen SP, Zhang GZ, Ju HY, Wang Y, Dong XB, Xu B. Resection of bilateral occipital lobe lesions during a single operation as a treatment for bilateral occipital lobe epilepsy. World J Clin Cases 2021; 9(34): 10518-10529 [PMID: 35004983 DOI: 10.12998/wjcc.v9.i34.10518]
Corresponding Author of This Article
Xiao-Fei Xu, MD, Doctor, Neurosurgery and Epilepsy Centre, General Hospital of Beijing Military Commanding Regain, No. 5 Nancangmen, Dongcheng District, Beijing 100700, China. xuxiaofei0002@126.com
Research Domain of This Article
Neurosciences
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Dec 6, 2021; 9(34): 10518-10529 Published online Dec 6, 2021. doi: 10.12998/wjcc.v9.i34.10518
Resection of bilateral occipital lobe lesions during a single operation as a treatment for bilateral occipital lobe epilepsy
Yan-En Lyu, Xiao-Fei Xu, Shuang Dai, Min Feng, Shao-Ping Shen, Guo-Zhen Zhang, Hong-Yan Ju, Yao Wang, Xiao-Bo Dong, Bin Xu
Yan-En Lyu, Min Feng, Yao Wang, Seventh Clinical School of Medicine, Beijing University of Chinese Medicine, Tongchuan 727031, Shaanxi Province, China
Yan-En Lyu, Shuang Dai, Shao-Ping Shen, Guo-Zhen Zhang, Hong-Yan Ju, Xiao-Bo Dong, Bin Xu, Neurosurgery and Epilepsy Centre, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
Xiao-Fei Xu, Neurosurgery and Epilepsy Centre, General Hospital of Beijing Military Commanding Regain, Beijing 100700, China
Author contributions: Lyu YE and Xu XF contributed conception, design and final approval of manuscript; Lyu YE, Xu XF, Dai S, Shen SP and Dong XB performed the research; Xu B, Zhang GZ and Ju HY contributed provision of study materials or patients; Lyu YE, Xu XF, Feng M and Wang Y contributed data collection and analysis; Lyu YE, Xu XF, Dai S, Feng M and Wang Y contributed manuscript writing.
Institutional review board statement: The ethics committee of Beijing university of Chinese medicine dongzhimen hospital approved this study. All patients provided written consent for surgery after being informed of the potential benefits and risks.
Informed consent statement: Informed consent for inclusion was waived because the analysis was retrospective.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Fei Xu, MD, Doctor, Neurosurgery and Epilepsy Centre, General Hospital of Beijing Military Commanding Regain, No. 5 Nancangmen, Dongcheng District, Beijing 100700, China. xuxiaofei0002@126.com
Received: June 7, 2021 Peer-review started: June 7, 2021 First decision: June 25, 2021 Revised: August 9, 2021 Accepted: October 6, 2021 Article in press: October 6, 2021 Published online: December 6, 2021
ARTICLE HIGHLIGHTS
Research background
Neurosurgical treatment of severe bilateral occipital lobe epilepsy usually involves two operations several mos apart.
Research motivation
The surgical treatment of bilateral occipital lobe epilepsy during a single operation would have several potential advantages, such as a reduced number of surgeries and hospitalizations, a shorter treatment time, lower treatment costs, and decreased psychological stress for the patients and their families.
Research objectives
To evaluate surgical resection of bilateral occipital lobe lesions during a single operation as a treatment for bilateral occipital lobe epilepsy.
Research methods
This retrospective case series included patients with drug-refractory bilateral occipital lobe epilepsy treated surgically between March 2006 and November 2015.
Research results
Most patients were free of disabling seizures (Engel grade I) postoperatively (18/20, 90.0%) and at 1 year (18/20, 90.0%), 3 years (17/20, 85.0%) and ≥ 5 years (17/20, 85.0%). No patients were classified Engel grade IV (no worthwhile improvement). After surgery, there was no change in visual function in 13/20 (65.0%), development of a new visual field defect in 3/20 (15.0%), and worsening of a preexisting defect in 4/20 (20.0%).
Research conclusions
Resection of bilateral occipital lobe lesions during a single operation may be applicable in bilateral occipital lobe epilepsy.
Research perspectives
A prospective, randomized clinical trial with a comparator group is needed to confirm our results.
