Wang XK, Zhou MH. Clinical features and survival of patients with multiple primary malignancies. World J Clin Cases 2021; 9(34): 10484-10493 [PMID: 35004980 DOI: 10.12998/wjcc.v9.i34.10484]
Corresponding Author of This Article
Min-Hang Zhou, MM, Attending Doctor, Department of Geriatric Oncology, the Fourth Medical Center, Chinese PLA General Hospital, No. 51 Fucheng Road, Beijing 100048, China. zhou_minhang@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Retrospective Cohort Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Dec 6, 2021; 9(34): 10484-10493 Published online Dec 6, 2021. doi: 10.12998/wjcc.v9.i34.10484
Clinical features and survival of patients with multiple primary malignancies
Xin-Kun Wang, Min-Hang Zhou
Xin-Kun Wang, Department of Radiology, the Fourth Medical Center, Chinese PLA General Hospital, Beijing 100048, China
Min-Hang Zhou, Department of Geriatric Oncology, the Fourth Medical Center, Chinese PLA General Hospital, Beijing 100048, China
Author contributions: Wang XK collected and analyzed the data, and drafted the work; Zhou MH performed the design of the work, the interpretation of data and revised the work; all authors read and approved the final manuscript.
Institutional review board statement: The study was approved by the institutional review board of our hospital (2020KY018-KS001).
Informed consent statement: The study was retrospective and the data were anonymous, so the requirement for informed consent was waived.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
STROBE statement: The authors have read the STROBE statement, and the manuscript was prepared and revised according to the STROBE statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Min-Hang Zhou, MM, Attending Doctor, Department of Geriatric Oncology, the Fourth Medical Center, Chinese PLA General Hospital, No. 51 Fucheng Road, Beijing 100048, China. zhou_minhang@163.com
Received: April 8, 2021 Peer-review started: April 8, 2021 First decision: April 28, 2021 Revised: May 9, 2021 Accepted: September 14, 2021 Article in press: September 14, 2021 Published online: December 6, 2021 Processing time: 235 Days and 19.1 Hours
ARTICLE HIGHLIGHTS
Research background
Multiple primary malignancies (MPM) are characterized by two or more primary malignancies in the same patient, excluding relapse or metastasis of prior cancer.
Research motivation
The clinical features and survival of MPM patients are not clear.
Research objectives
We aimed to elucidate the clinical features and survival of MPM patients.
Research methods
A retrospective study of MPM patients was conducted in our hospital between June 2016 and June 2019. Overall survival (OS) was calculated using the Kaplan-Meier method.
Research results
A total of 243 patients with MPM, including 222 patients with two malignancies and 21 patients with three malignancies. Following multivariate analyses, age > 65 years and distant metastasis were independent adverse prognostic factors for OS.
Research conclusions
During the diagnosis, treatment and follow-up of the initial cancer, more attention should be paid to the occurrence of a second, or even a third cancer in patients with MPM.
Research perspectives
For common MPM pairs, such as NSCLC and breast/gastric cancer, colorectal and gastric cancer, the risk of concomitant MPM should be closely monitored, to ensure early detection and treatment of the subsequent cancer.
