Published online Dec 6, 2021. doi: 10.12998/wjcc.v9.i34.10484
Peer-review started: April 8, 2021
First decision: April 28, 2021
Revised: May 9, 2021
Accepted: September 14, 2021
Article in press: September 14, 2021
Published online: December 6, 2021
Multiple primary malignancies (MPM) are characterized by two or more primary malignancies in the same patient, excluding relapse or metastasis of prior cancer.
The clinical features and survival of MPM patients are not clear.
We aimed to elucidate the clinical features and survival of MPM patients.
A retrospective study of MPM patients was conducted in our hospital between June 2016 and June 2019. Overall survival (OS) was calculated using the Kaplan-Meier method.
A total of 243 patients with MPM, including 222 patients with two malignancies and 21 patients with three malignancies. Following multivariate analyses, age > 65 years and distant metastasis were independent adverse prognostic factors for OS.
During the diagnosis, treatment and follow-up of the initial cancer, more attention should be paid to the occurrence of a second, or even a third cancer in patients with MPM.
For common MPM pairs, such as NSCLC and breast/gastric cancer, colorectal and gastric cancer, the risk of concomitant MPM should be closely monitored, to ensure early detection and treatment of the subsequent cancer.