Published online Dec 6, 2021. doi: 10.12998/wjcc.v9.i34.10464
Peer-review started: July 19, 2021
First decision: August 19, 2021
Revised: August 22, 2021
Accepted: October 12, 2021
Article in press: October 12, 2021
Published online: December 6, 2021
Idiopathic membranous nephropathy (IMN) has a high incidence in the middle-aged and elderly population, and poses a great threat to the physical and mental health and quality of life of patients. The incidence of IMN has continued to increase in recent years, and safe and effective treatments are of significant research interest.
Glucocorticoid therapy alone has difficulty achieving ideal effects in IMN, and the incidence of adverse reactions is high. Tacrolimus is a new calcineurin inhibitor that can effectively improve renal function with low dose and high safety.
This study aimed to investigate the efficacy and safety of Nephritis Rehabilitation Tablets combined with tacrolimus in the treatment of IMN.
On the basis of routine symptomatic treatment, the control group was treated with tacrolimus, and the study group was treated with nephritis rehabilitation tablets in addition to control group treatment. Both groups were treated for 12 wk. The therapeutic effect, the levels of renal function indexes, and the incidence of adverse reactions were measured before and after 12 wk of treatment.
The results showed that the total effective rate of the study group was higher than that of the control group, the quantitative levels of Scr and 24-h urinary protein of the study group were lower than those of the control group, and the level of serum albumin was higher than that of the control group. IMN autoantibodies play an intermediary role, while complement proteins play an important role in organ-specific autoimmune diseases. The levels of urinary IgG4 and C5b-9 in the study group were lower than those in the control group.
Nephritis Rehabilitation Tablets combined with tacrolimus in the treatment of IMN can effectively improve the renal function of patients and downregulate the expression of urinary IgG4 and C5b-9. In addition, they can improve the overall therapeutic effect while not increasing the risk of adverse reactions.
This study has fewer samples, and further multi-center research is required to confirm our findings.