Chen M, Fang Y, Yang Y, He PJ, Cheng L, Wu HT. Circulating immune parameters-based nomogram for predicting malignancy in laryngeal neoplasm. World J Clin Cases 2021; 9(3): 540-551 [PMID: 33553392 DOI: 10.12998/wjcc.v9.i3.540]
Corresponding Author of This Article
Hai-Tao Wu, PhD, Chief Physician, Doctor, Surgeon, Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose, and Throat Hospital of Fudan University, No. 83 Fenyang Road, Shanghai 200031, China. eentwuhaitao@163.com
Research Domain of This Article
Otorhinolaryngology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jan 26, 2021; 9(3): 540-551 Published online Jan 26, 2021. doi: 10.12998/wjcc.v9.i3.540
Circulating immune parameters-based nomogram for predicting malignancy in laryngeal neoplasm
Min Chen, Yi Fang, Yue Yang, Pei-Jie He, Lei Cheng, Hai-Tao Wu
Min Chen, Yi Fang, Yue Yang, Pei-Jie He, Lei Cheng, Hai-Tao Wu, Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai 200031, China
Author contributions: Chen M performed the study, analyzed data and wrote the original manuscript; Fang Y collected data and corrected the manuscript; Yang Y participated in data analysis and study design; He PJ and Cheng L reviewed and edited the manuscript; Wu HT designed the study and corrected the manuscript.
Supported byHealth and Family Planning Commission of Shanghai Municipality of China, No. 2019SY059.
Institutional review board statement: The study was reviewed and approved by the Eye, Ear, Nose, and Throat Hospital of Fudan University Institutional Review Board (Approval No. 2017042-1).
Informed consent statement: All patients gave informed consent.
Conflict-of-interest statement: No potential conflict of interest was reported by the authors.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai-Tao Wu, PhD, Chief Physician, Doctor, Surgeon, Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose, and Throat Hospital of Fudan University, No. 83 Fenyang Road, Shanghai 200031, China. eentwuhaitao@163.com
Received: August 6, 2020 Peer-review started: August 6, 2020 First decision: November 14, 2020 Revised: November 28, 2020 Accepted: December 10, 2020 Article in press: December 10, 2020 Published online: January 26, 2021 Processing time: 166 Days and 23.7 Hours
ARTICLE HIGHLIGHTS
Research background
Malignancy prediction remains important to preoperative diagnosis and postoperative follow-up in laryngeal neoplasm.
Research motivation
There are continuing problems in differentiating premalignant lesions from malignant lesions of the larynx before surgery.
Research objectives
To evaluate the circulating immune population and develop a nomogram for prediction of malignancy in patients with laryngeal neoplasm.
Research methods
Peripheral blood from patients with laryngeal neoplasm was analyzed by blood routine test and flow cytometry. Circulating immune population and clinical parameters were screened to develop a predictive model for risk of laryngeal cancer, which was presented by a nomogram.
Research results
The nomogram incorporated predictors, including gender, age, smoke index, proportions of monocytes, CD8+ T cells, CD4+ T cells and B cells and CD4/CD8 + T cell ratio, showed good discrimination between laryngeal premalignant lesions and malignant lesions.
Research conclusions
This circulating immune cell parameter-based novel nomogram could be appropriately applied in preoperative individualized prediction of malignancy in patients with laryngeal neoplasm.
Research perspectives
Future research should be undertaken to assess the external validation of the nomogram in multiple institutions. Confirmatory studies investigating functional mechanism of circulating immune populations for laryngeal carcinogenesis are desirable.
