Published online Jan 26, 2021. doi: 10.12998/wjcc.v9.i3.540
Peer-review started: August 6, 2020
First decision: November 14, 2020
Revised: November 28, 2020
Accepted: December 10, 2020
Article in press: December 10, 2020
Published online: January 26, 2021
Malignancy prediction remains important to preoperative diagnosis and postoperative follow-up in laryngeal neoplasm.
There are continuing problems in differentiating premalignant lesions from malignant lesions of the larynx before surgery.
To evaluate the circulating immune population and develop a nomogram for prediction of malignancy in patients with laryngeal neoplasm.
Peripheral blood from patients with laryngeal neoplasm was analyzed by blood routine test and flow cytometry. Circulating immune population and clinical parameters were screened to develop a predictive model for risk of laryngeal cancer, which was presented by a nomogram.
The nomogram incorporated predictors, including gender, age, smoke index, proportions of monocytes, CD8+ T cells, CD4+ T cells and B cells and CD4/CD8 + T cell ratio, showed good discrimination between laryngeal premalignant lesions and malignant lesions.
This circulating immune cell parameter-based novel nomogram could be appropriately applied in preoperative individualized prediction of malignancy in patients with laryngeal neoplasm.
Future research should be undertaken to assess the external validation of the nomogram in multiple institutions. Confirmatory studies investigating functional mechanism of circulating immune populations for laryngeal carcinogenesis are desirable.