Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 6, 2021; 9(28): 8349-8357
Published online Oct 6, 2021. doi: 10.12998/wjcc.v9.i28.8349
Clinical observation of Kuntai capsule combined with Fenmotong in treatment of decline of ovarian reserve function
Xin-Miao Lin, Miao Chen, Qiao-Ling Wang, Xiao-Min Ye, Hao-Fan Chen
Xin-Miao Lin, Miao Chen, Qiao-Ling Wang, Xiao-Min Ye, Hao-Fan Chen, Department of Reproductive Health and Infertility, Zhanjiang Central People’s Hospital, Zhanjiang 524037, Guangdong Province, China
Author contributions: Lin XM designed the experiment; Chen M drafted the work, Chen HF, Wang QL and Ye XM collected the data; Lin XM analysed and interpreted data; Chen M wrote the article. Lin XM and Chen M contributed equally.
Institutional review board statement: This manuscript was approved by the Medical Ethics Committee of Zhanjiang Central Hospital.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: The authors declared that there is no conflict of interest between them.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Hao-Fan Chen, PhD, Chief Doctor, Department of Reproductive Health and Infertility, Zhanjiang Central People’s Hospital, No. 236 Yuanzhu Road, Chikan District, Zhanjiang 524037, Guangdong Province, China.
Received: May 27, 2021
Peer-review started: May 27, 2021
First decision: June 24, 2021
Revised: July 4, 2021
Accepted: August 5, 2021
Article in press: August 5, 2021
Published online: October 6, 2021
Research background

Decreased ovarian reserve function, also known as premature ovarian failure, is characterized by a decrease in the level of estrogen in the body, resulting in a series of low-estrogen symptoms that adversely affect the physical and mental health of patients.

Research motivation

From the direction of traditional Chinese medicine (TCM) to find ways to treat the decline of ovarian reserve.

Research objectives

This study aimed to observe the clinical manifestations of Kuntai capsule combined with Fenmotong in treating decline of ovarian reserve function.

Research methods

Patients (130) with decreased ovarian reserve function, were divided into two groups: The FMT group, and the observation group, in which patients were treated with Kuntai capsules. The clinical indexes including TCM symptom score and uterine artery blood flow parameters were recorded, and the total effective rate of the two groups was counted.

Research results

The total effective rate in the observation group was higher than that in the FMT group (P < 0.05). Secondary symptoms decreased in both groups, and the scores of primary and secondary symptoms in the observation group were lower than those in the femoston group (P < 0.05).The observation group was more conducive to promoting uterine artery blood circulation, improving ovarian blood supply, preventing ovarian atrophy, and facilitating follicular formation.

Research conclusions

Effect of Kuntai capsule combined with femoston on ovarian reserve function decline is better than that of femoston alone.

Research perspectives

Therefore, we did not observe pregnancy and delivery rates for the patients after treatment. Therefore, in future clinical studies, patients with fertility problems can be screened to further explore whether Kuntai capsules combined with FMT could increase fertility rates in the treatment of ovarian reserve function decline.