Published online Oct 6, 2021. doi: 10.12998/wjcc.v9.i28.8340
Peer-review started: June 10, 2021
First decision: July 5, 2021
Revised: July 10, 2021
Accepted: August 16, 2021
Article in press: August 16, 2021
Published online: October 6, 2021
Gestational diabetes mellitus and gestational hypertension disease are common pregnancy complications. In addition to the traditional pathogenic factors, new types of environmental exposure have attracted more and more attention. With the continuous development of emerging technologies, nickel (Ni)-containing products are widely used in production and in life. Ni may accumulate in the human body and has biological toxicity and carcinogenicity. Ni has a more extensive impact on the health of pregnant women and fetuses during gestation.
This study has important reference significance for reducing Ni exposure during pregnancy, improving the quality of the living environment and ensuring the normal development of the fetus.
This study aimed to evaluate Ni exposure in pregnant women in Kunming, Yunnan Province, China.
Basic information on the 72 pregnant women was collected by questionnaire survey. Maternal blood, placenta blood and cord blood were collected immediately after delivery. The Ni content in paired samples was determined using inductively coupled plasma mass spectrometry.
It was found that pregnant women in Kunming, Yunnan Province experienced environmental exposure to Ni, which can be transferred to the fetus through the placental barrier.
In the maternal-fetal system of women with pregnancy complications, the barrier effect of the placenta against Ni is weakened, thus affecting healthy growth of the fetus in the uterus.
Further research into the mechanisms, from the perspective of advanced molecular biology, will reveal the key role of nickel in gestational disease, placental barrier and birth outcome.