Zhang H, Gong J, Ma LS, Jiang T, Zhang H. Effect of antifoaming agent on benign colorectal tumors in colonoscopy: A meta-analysis. World J Clin Cases 2021; 9(15): 3607-3622 [PMID: 34046460 DOI: 10.12998/wjcc.v9.i15.3607]
Corresponding Author of This Article
Heng Zhang, MA, MD, Chief Doctor, Department of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, No. 26 Shengli Street, Jiangan District, Wuhan 430014, Hubei Province, China. 653262549@qq.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. May 26, 2021; 9(15): 3607-3622 Published online May 26, 2021. doi: 10.12998/wjcc.v9.i15.3607
Effect of antifoaming agent on benign colorectal tumors in colonoscopy: A meta-analysis
Hu Zhang, Jing Gong, Lin-Song Ma, Ting Jiang, Heng Zhang
Hu Zhang, Jing Gong, Lin-Song Ma, Ting Jiang, Heng Zhang, Department of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, Hubei Province, China
Hu Zhang, Department of Gastroenterology, The Eighth Hospital of Wuhan, Wuhan 430014, Hubei Province, China
Author contributions: Heng Z designed this study and critically revised the manuscript; Hu Z and JL were responsible for data acquisition and extraction; Hu Z drafted the manuscript, analyzed the data, and interpreted the results; Hu Z, Ma LS, Jiang T, and Gong J were involved in editing the manuscript; All authors read and approved the final manuscript.
Supported bythe Natural Science Foundation of Wuhan, No. WX18Y04.
Conflict-of-interest statement: All of the authors declare that they have no conflicts of interest regarding this paper.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist statement, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Heng Zhang, MA, MD, Chief Doctor, Department of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, No. 26 Shengli Street, Jiangan District, Wuhan 430014, Hubei Province, China. 653262549@qq.com
Received: January 3, 2021 Peer-review started: January 3, 2021 First decision: February 11, 2021 Revised: February 25, 2021 Accepted: March 12, 2021 Article in press: March 12, 2021 Published online: May 26, 2021 Processing time: 127 Days and 23.4 Hours
ARTICLE HIGHLIGHTS
Research background
The incidence and mortality of colorectal cancer have been rapidly increasing in Asian countries, and inadequate bowel preparation is related to an increased risk of missed benign colorectal tumors and more discomfort for patients.
Research motivation
Simethicone is an effective and safe antifoaming agent for use during endoscopic procedures. A combination of simethicone and polyethylene glycol has been shown to improve the visualization of the bowel for colonoscopy.
Research objectives
We performed a meta-analysis to investigate its effect on the detection of benign colorectal tumors.
Research methods
The PubMed, EMBASE, and Cochrane Library databases were searched for articles published.
Research results
A significant effect of simethicone for diminutive adenomas (< 10 mm) and the adenoma detection rate in the proximal colon were revealed in the group taking simethicone. Moreover, it was a significant finding that the low dose simethicone was as effective as the high dose one with respect to the detection of colorectal benign tumors.
Research conclusions
The addition of simethicone to polyethylene glycol might improve the detection of diminutive adenomas in the right colon by colonoscopy in Asia. Low-dose simethicone was recommended for the detection of benign colorectal tumors.
Research perspectives
We believe that simethicone might improve small adenoma detection rates, especially in the proximal colon for colonoscopy in Asians with low baseline adenoma detection rates.
