Published online Jan 6, 2021. doi: 10.12998/wjcc.v9.i1.24
Peer-review started: June 27, 2020
First decision: September 30, 2020
Revised: October 9, 2020
Accepted: November 2, 2020
Article in press: November 2, 2020
Published online: January 6, 2021
Oesophageal signet ring cell carcinoma is a rare type of cancer, and log odds of positive lymph nodes (LODDS) may be a better prognostic factor for it.
To investigate the predictive value of LODDS for signet ring cell carcinoma of the oesophagus.
To explore whether LODDS is a better prognostic factor than N stage for oesophageal signet ring cell carcinoma.
The prognostic values of LODDS and N stage for oesophageal signet ring cell carcinoma were evaluated by univariate and multivariate analyses. The Akaike information criterion and Harrell’s C-index were used to compare the predictive value of the model. External validation was performed to further confirm the conclusion.
The multivariate Cox regression model showed that LODDS was a significant independent prognostic factor for oesophageal signet ring carcinoma patients. LODDS has better predictive value than N stage. The results of external validation were consistent with those in the study cohort.
LODDS is a superior prognostic factor for patients with oesophageal signet ring cell carcinoma after oesophagectomy than N stage.
In the future, it is expected that there will be more studies on oesophageal signet ring cell cancer, and the treatment and diagnosis of this cancer will be continuously improved.