Retrospective Cohort Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 6, 2020; 8(9): 1608-1619
Published online May 6, 2020. doi: 10.12998/wjcc.v8.i9.1608
Prognosis factors of advanced gastric cancer according to sex and age
Abdulaziz Alshehri, Hussain Alanezi, Beom Su Kim
Abdulaziz Alshehri, Hussain Alanezi, Beom Su Kim, Department of Gastric Surgery, Ulsan University School of Medicine, Asan Medical Center, Seoul 05505, South Korea
Abdulaziz Alshehri, General Surgery Department, King Fahad Military Medical Complex, Dhahran 31932, Saudi Arabia
Hussain Alanezi, Department of General Surgery, Northern Area Armed Forces Hospital, Hafar Al Batin 31991, Saudi Arabia
Institutional review board statement: The study was reviewed and approved for publication by our Institutional Reviewer.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All the Authors have no conflict of interest related to the manuscript.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Beom Su Kim, MD, PhD, Professor, Surgeon, Department of Gastric Surgery, Ulsan University School of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songp-gu, Seoul 05505, South Korea. bskim0251@naver.com
Received: February 22, 2020
Peer-review started: February 22, 2020
First decision: March 18, 2020
Revised: March 26, 2020
Accepted: April 24, 2020
Article in press: April 24, 2020
Published online: May 6, 2020
Processing time: 67 Days and 23.4 Hours
ARTICLE HIGHLIGHTS
Research background

Gastric cancer has a relatively high prevalence specially in east countries. However the prognosis still poor with those advanced cases. Despite the improvement in diagnostic and treatment.

Research motivation

Although outcomes of advanced gastric cancer is not satisfied. Searching for factors may improve the result and outcomes of treatment may help to improve the prognosis.

Research objectives

This study aimed to see the prognosis factors in advanced gastric cancer according to patient’s age and gender.

Research methods

2005 patients with advanced gastric cancer who underwent surgical treatment at one Korean single centre between 2002-2007. Retrospectively, data collected and analyzed. Possible prognosis factors were evaluated.

Research results

A total of 2005 patients [sex, 1384 men (69%), 621 women (31%)] with advanced gastric cancer. Cox proportional hazards model, overall survival was independently predicted by older age, larger tumour size, lymphovascular invasion, lymph node metastasis, deeper tumour invasion, moderately-to-poorly differentiated tubular adenocarcinoma, and signet ring cell carcinoma. The same model revealed that relapse-free survival was independently predicted by advanced age, larger tumour size, lymphovascular invasion, deeper tumour invasion, poorly differentiated tubular adenocarcinoma, and signet ring cell carcinoma.

Research conclusions

Older age was independently predicted factor for poor overall survival and relapse-free survival. However, there were no significant difference found according to gender in relapse-free and overall survival.

Research perspectives

Study was limited by the small sample size and the lack of a control group. Nevertheless, we provided new data regarding a disease with an increasing incidence in younger patients and adults, which has considerable psychological and social effects. Increased awareness of advanced gastric cancer is needed to ensure that gastric cancer is diagnosed at a potentially curable stage.