Retrospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 26, 2020; 8(4): 736-742
Published online Feb 26, 2020. doi: 10.12998/wjcc.v8.i4.736
Effectiveness of surgical resection for complicated liver cancer and its influencing factors: A retrospective study
Jian Yu, Zhi-Zheng Wu, Teng Li, Ying Xu, Yu-Cheng Zhao, Bo-Lun Zhang, Hu Tian
Jian Yu, Zhi-Zheng Wu, Teng Li, Ying Xu, Yu-Cheng Zhao, Bo-Lun Zhang, Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong Province, China
Teng Li, Yu-Cheng Zhao, Department of General Surgery, the First Affiliated Hospital of Shandong First Medical University, Taian 271016, Shandong Province, China
Hu Tian, Department of Hepatological Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong Province, China
Author contributions: Yu J, Wu ZZ, Li T, Xu Y, and Zhao YC designed this retrospective study; Zhang BL and Tian H wrote this paper; Yu J and Tian H were responsible for sorting the data.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Shandong Provincial Qianfoshan Hospital, Shandong University.
Informed consent statement: Informed consent was obtained from the patient.
Conflict-of-interest statement: Dr. Tian reports grants from the Medical Technology Innovation Plan of Jinan City (201805033), Key Research and Development Plan of Shandong Province (2016GSF201108), and Science and Technology Development Plan of Shandong Province (ZR2019MH116) during this study.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hu Tian, MD, PhD, Chief Doctor, Professor, Surgeon, Department of Hepatological Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, No. 16766, Jingshi Road, Lixia District, Jinan 250014, Shandong Province, China. tianhu6585@163.com
Received: December 1, 2019
Peer-review started: December 1, 2019
First decision: December 23, 2019
Revised: January 12, 2020
Accepted: January 15, 2020
Article in press: January 11, 2020
Published online: February 26, 2020
Processing time: 87 Days and 1.3 Hours
ARTICLE HIGHLIGHTS
Research background

Surgical resection is the preferred method for patients with complex liver cancer. But the tumor is in a special position, the surgery is highly risky, postoperative complications can easily occur, and the prognosis is not ideal.

Research motivation

To explore the safety and feasibility of complicated liver cancer surgery and improve the survival rate of patients.

Research objectives

To investigate the effectiveness of surgical resection for complex liver cancer and its influencing factors.

Research methods

Fifty-seven patients who had complicated liver cancer and underwent surgical resection at our hospital from August 2015 to August 2016 were enrolled in this study. All patients were followed for three years, and their postoperative complications, survival, and factors that impacted their survival were analyzed.

Research results

The total incidence of postoperative complications was 45.61%, and the incidence of pleural effusion was the highest at 28.07%. There were no correlations between the 2-year and 3-year survival rates and sex, age, and HbsAg of the patients (P > 0.05). In terms of pathological parameters, the 2-year survival rates and 3-year survival rates were significantly different according to the presence of a tumor capsule, degree of liver cirrhosis, satellite or foci lesions, hepatic vein thrombosis, portal vein tumor thrombus, and intraoperative blood loss (P < 0.05).

Research conclusions

The effectiveness of surgical resection for complex hepatocellular carcinoma may be affected by factors such as the presence of a tumor capsule, cirrhosis degree, satellite or focal lesions, hepatic vein embolization, portal vein tumor thrombus, and intraoperative blood loss. Therefore, these factors should be controlled and prevented during surgery to help improve patient survival after surgery.

Research perspectives

The influencing factors of complicated hepatocellular carcinoma surgery should be further explored to further improve patient survival after surgery.