Published online Feb 26, 2020. doi: 10.12998/wjcc.v8.i4.670
Peer-review started: December 3, 2019
First decision: December 23, 2019
Revised: February 4, 2020
Accepted: February 12, 2020
Article in press: February 12, 2020
Published online: February 26, 2020
Processing time: 85 Days and 7.3 Hours
Gastrointestinal perforation (GIP) is a common acute abdominal injury. It usually requires active rescue in the intensive care unit with an emergency laparotomy. The definition of sepsis was revised in 2016 (sepsis 3.0) to better reflect the prognosis and organ function damage rather than being defined as infection-induced systemic inflammatory response syndrome. Once sepsis occurs, the prognosis worsens, and few studies have focused on the risk factors for postoperative sepsis in patients with GIP.
In 2016, the definition of sepsis was revised. According to the revision, patients with postoperative sepsis would be at a higher risk for death. As a result, we thought an investigation of the risk factors for postoperative sepsis was very necessary.
This study aimed to investigate the risk factors for postoperative sepsis in patients with GIP.
From January 2016 to December 2018, the medical records of patients with GIP, receiving emergency surgery, were retrospectively reviewed and analyzed. Risk factors for postoperative sepsis in patients with GIP were evaluated.
A total of 212 patients were eligible. The prevalence of postoperative sepsis was 22.6% [95% confidence interval (CI): 17.0%-28.3%, n = 48]. The time interval from abdominal pain to emergency surgery [odds ratio (OR) = 1.021, 95%CI: 1.005-1.038, P = 0.006], colonic perforation (OR = 2.761, CI: 1.821-14.776, P = 0.007), diameter of perforation (OR = 1.062, 95%CI: 1.007-1.121, P = 0.027), and the incidence of malignant tumor-related perforation (OR = 5.384, 95%CI: 1.762-32.844, P = 0.021) were associated with postoperative sepsis.
The time interval from abdominal pain to emergency surgery, colonic perforation, diameter of perforation, and the incidence of malignant tumor-related perforation were risk factors for postoperative sepsis in patients with GIP.
A further study plans to include more subjects and the development of a prediction model for postoperative sepsis, in order to identify a truly accurate diagnostic method suitable for clinical use.